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_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.11.30.M.Sc.2016.Ah.E | ||
| 100 | 0 | _aAhmed Mohamed Siddiq | |
| 245 | 1 | 0 |
_aEffects of }-3 fatty acids and estrogen replacement therapy on ovariectomy induced osteoporosis in female albino rats / _cAhmed Mohamed Siddiq ; Supervised Nahed Salah Eldin Mohamed , Mohamed Alsayed Saleh , Ayman Saied Soliman |
| 246 | 1 | 5 | _aتأثير الأحماض الدهنية أوميجا 3 و العلاج التعويضي بالإستروجين على هشاشة العظام بعد استئصال المبيضين في إناث الجرذان البيضاء |
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_aCairo : _bAhmed Mohamed Siddiq , _c2016 |
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_a124 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Physiology | ||
| 520 | _aFatty acids especially omega 3 unsaturated fatty acids has known anti-inflammatory effects. And there are different mechanisms by which dietary fatty acids may affect bone, but there protective effect against postmenopausal osteoporosis remains a controversial issue. This study was applied on 50 female albino rats that were divided into 5 equal groups: sham operated group, ovariectomy group, ovariectomy + flaxseed oil group (0.4 g per day), ovariectomy + fish oil administered group (0.4 g per day) and ovariectomy + estrogen replacement therapy group (30 æg/kg 5 days a week). The study proceeded for 12 weeks then femurs bone mineral density (BMD) were measured with dual-energy X-ray absorptiometer (DXA) scan and serum osteoprotogerin (OPG), bone specific alkaline phosphatase (ALP-b) and tumour necrosis factor alpha (TNF-Ü) were measured. There was a significant increase in the BMD of the treated groups compared with the ovariectomy group (p < .01). There were a significant differences in the means of serum bone markers measures of the treated groups versus the ovariectomy group in the form of significant increase in OPG (p < .001) and a significant decrease in ALP-b (p < .001) and TNF-Ü (p < .001) of the treated groups compared with the ovariectomy group. This study showed a significant negative correlation between BMD and ALP-b (r = - 0.375, p < .001). According to this study the chronic administration of omega 3 fatty acids (flaxseed oil - fish oil) has a preventive effect against osteoporosis and suppression of bone turn over process appears to have a role in this preventive effect | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aBone mineral density | |
| 653 | 4 | _aOmega 3 fatty acids | |
| 653 | 4 | _aOsteoporosis | |
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_aAyman Saied Soliman , _eSupervisor |
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_aMohamed Alsayed Saleh , _eSupervisor |
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| 700 | 0 |
_aNahed Salah Eldin Mohamed , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
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_aEnas _eCataloger |
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_aNazla _eRevisor |
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_2ddc _cTH |
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