000 02484cam a2200349 a 4500
003 EG-GiCUC
005 20250223031534.0
008 161004s2015 ua d f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aPh.D
099 _aCai01.11.01.Ph.D.2015.Di.I
100 0 _aDina Atteya Mohamed Atteya
245 1 0 _aImpact of augmented renal clearnce on enoxaparin therapy in critically ill pateints /
_cDina Atteya Mohamed Atteya ; Supervised Hala Ezzat Mohamed Abdelnaeem , Mona Hossam Eldin Abdelhameed , Ahmed Mohamed Ibrahim Hasanin
246 1 5 _aتأثير زيادة التنقية الكلوية على علاج بالإينوكسبارين في مرضى الحالات الحرجة
260 _aCairo :
_bDina Atteya Mohamed Atteya ,
_c2015
300 _a58 P. :
_bcharts ;
_c25cm
502 _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Anaesthesia
520 _aFifty critically ill patients receiving enoxaparin prophylactic dose (40mg/day) were included in the study. Creatinine clearance was measured and patients were divided into two groups: normal kidney function group (group C) and augmented renal clearance group (group A). serum anti-factor Xa was measured at baseline, four hours, 12 hours, and 24 hours. Both groups were compared regarding demographic data, severity scores, kidney function, and anti-factor Xa activity.Results Twenty patients (40%) showed ARC and thirty patients (60%) showed normal kidney function. Creatinine clearance was 214±6 in group A versus 112±11 in group C (P=0.001). Serum anti-factor Xa levels was similar in the two groups after four hours (0.2±0.07 Vs 0.2±0.05, P=1). Serum anti-Xa levels were significantly lower in group A compared to group C at 12 and 24 hours (0.06±0.03 Vs 0.1±0.04, P=0.004), (0.01±0.01 Vs 0.05±0.01, P=0.001) respectively.Conclusion ARC patients showed short activity of enoxaparin. This finding draws the attention towards dose adjustment in this type of patients
530 _aIssued also as CD
653 4 _aAnaesthesia
653 4 _aCritically ill
653 4 _aEnoxaparin therapy
700 0 _aAhmed Mohamed Ibrahim Hasanin ,
_eSupervisor
700 0 _aHala Ezzat Mohamed Abdelnaeem ,
_eSupervisor
700 0 _aMona Hossam Eldin Abdelhameed ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aEnas
_eCataloger
905 _aNazla
_eRevisor
942 _2ddc
_cTH
999 _c57340
_d57340