000			02925cam a2200337 a 4500
003			EG-GiCUC
005			20250223031539.0
008			160821s2015 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.15.M.Sc.2015.Mo.R
100	0		_aMohamed Aly Hassan Aly
245	1	2	_aA randomized trial of combined letrozole with metformin versus clomiphene citrate with metformin in PCOS patients / _cMohamed Aly Hassan Aly ; Supervised Abdelmaguid Ramzy , Hossam ElShenoufy
246	1	5	_aدراسة عشوائية مقارنة على ليتروزول مع الميتفورمين مقارنة بالكلوميفين سترات مع الميتفورمين في حالات تكيس المبيض
260			_aCairo : _bMohamed Aly Hassan Aly , _c2015
300			_a99 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Gynecology and Obstetrics
520			_aPolycystic Ovary Syndrome (PCOS) is one of the most common causes of anovulatory infertility. Currently, CC is considered first-line therapy for ovulation induction for women with PCOS and infertility Aromatase inhibitors (AIs) have been introduced as a new treatment option that could challenge CC for ovulation induction The present study was designed to compare the efficacy of combined aromatase inhibitors (Letrozole) with metformin versus CC with metformin in PCOS patients This study was done on 100 documented PCOS cases. They were divided to two groups, The 1st group received CC 50mg twice daily from the 3rd day of cycle for 5 days and repeated for 3 cycles with metformin 500mg 3 times daily as an adjunct with CC and continued for 3 cycles. The 2nd group received aromatase inhibitor (Letrozole) 2.5 mg twice daily from 3rd day of cycle for 5 days and repeated for 3 cycles with metformin 500mg 3 times daily as an adjunct with letrozole and continued for 3 cycles. These cases were followed up for three cycles by transvaginal ultrasound folliculometry to document ovulation (size and number of follicles). The results of the present study revealed both lines of treatment were effective in treatment of PCOS patients, with slight favorability in letrozole group but without statistically significant difference founded between CC group and letrozole group as regard ovulation rate, number of follicles in the end of first, second or third cycles, or as regard the diameter of follicles, i.e., both regimens showed efficacy to the same extent
530			_aIssued also as CD
653		4	_aClomiphene citrate
653		4	_aLetrozole
653		4	_aPCOS
700	0		_aAbdelmaguid Ramzy , _eSupervisor
700	0		_aHossam ElShenoufy , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aEnas _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c57495 _d57495