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003 EG-GiCUC
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008 160827s2016 ua dh f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aPh.D
099 _aCai01.08.03.Ph.D.2016.Ba.A
100 0 _aBasma Mohamed Abdelhameed Eltanany
245 1 0 _aAnalysis of some multicomponent preparations used for treatment of mucous membranes disorders /
_cBasma Mohamed Abdelhameed Eltanany ; Supervised Fatma Issa Khattab , Maha Abdelmonem Hegazy , Medhat Ahmed Alghobashy
246 1 5 _aتحليل بعض المستحضرات متعددة المحتوى المستخدمة لعلاج الأغشية المخاطية
260 _aCairo :
_bBasma Mohamed Abdelhameed Eltanany ,
_c2016
300 _a272 P. :
_bcharts , facsimiles ;
_c25cm
502 _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry
520 _aMucous membranes including vaginal, nasal and mouth membranes are vulnerable to different disorders such as inflammation, congestion, fungal and/or bacterial infections. For sufficient treatment of these disorders, local and/or systemic multicomponent pharmaceutical preparations are used. Nasal preparations include ingredients such as antihistamines, alpha agonists, anti- inflammatory and others. The active ingredients cover a range of structures with widely varying polarities and include both acidic and basic compounds. Phenylephrine, Dimetindene Maleate, Carbinoxamine Maleate, Sodium Cromoglycate and Oxymetazoline Hydrochloride are widely used in combinations for the clinical treatment of common cold, sinusitis, bronchitis and respiratory allergies. The aim of this work was to develop potential, reliable fast and efficient analytical methodologies for various dosage forms which can estimate all the major ingredients of multicomponent formulations used for treatment of mucous membranes disorders. Also to investigate purity using analytical methods which are capable of determining the studied drugs in their combinations and in presence of their impurities. Various analytical techniques were used for the simultaneous analysis of these mixtures. The proposed methods were simple, accurate, and reproducible, which would be feasible, and sensitive for the determination of the studied drugs. The proposed methods were validated according to ICH-guidelines
530 _aIssued also as CD
653 4 _aDimetindence Maleate
653 4 _aMucous memberanes disorders
653 4 _aPhenylephrine
700 0 _aFatma Issa Khattab ,
_eSupervisor
700 0 _aMaha Abdel Monem Hegazy ,
_eSupervisor
700 0 _aMedhat Ahmed Alghobashy ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aSamah
_eCataloger
942 _2ddc
_cTH
999 _c57565
_d57565