000			03252cam a2200349 a 4500
003			EG-GiCUC
005			20250223031544.0
008			160907s2016 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.12.21.M.Sc.2016.Sh.P
100	0		_aShreen Desokey Abdelhamed
245	1	4	_aThe potential therapeutic effect of Origanum majorana extract against hepatorenal toxicity induced by cisplatin in male albino rats / _cShreen Desokey Abdelhamed ; Supervised Mohamed Marzouk Mohamed , Amel Mahmoud Soliman , Amany Ahmed Sayed
246	1	5	_aالتأثير العلاجي المحتمل لمستخلص البردقوش ضد السمية الكبدية الكلوية المستحثة بالسيسبلاتين في ذكور الجرذان
260			_aCairo : _bShreen Desokey Abdelhamed , _c2016
300			_a167 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology
520			_aCisplatin (CDDP) is a widely potent anticancer drug used in chemotherapy, unfortunately it elicits major undesirable side effects in various tissues, including liver and kidney. The aim of the present study was to investigate whether Origanum majorana ethanolic extract (OMEE) can reduce cisplatin-induced hepatorenal toxicity. The effectiveness of OMEE was compared with silymarin as a standard hepatoprotective drug. Male albino rats were divided into four groups (6 rats/group). Rats of the control group were administered distilled water for 17 consecutive days. The rest of rats were received a single intraperitoneal injection of CDDP (3 mg/kg body weight), then after 3 days, rats were administered orally for 14 days distilled water (CDDP group) or OMEE (500 mg/kg/day) (OMEE group) or silymarin (150 mg/kg/day). CDDP-induced hepatorenal toxicity was assessed biochemically by an increase in levels of serum ASAT, ALAT, ÞGT, LDH, ALP, total bilirubin, creatinine, urea, uric acid, BUN, total lipid, triglycerides and LDL-cholesterol. In addition, a decrease in serum total protein, albumin and HDL-cholesterol concentrations was recorded in comparison with the control group. Meanwhile, CDDP-induced an oxidative stress, which evidenced by a significant increase in hepatic and renal MDA, NO levels as well as a significant reduction in hepatic and renal GSH, SOD, GST and CAT contents as compared to the corresponding one of control group. Liver and kidney histopathological changes were observed in the cisplatin group as compared to the control group. Interestingly, oral administration of OMEE or silymarin significantly ameliorates the abnormal effects of CDDP on nearly all the studied parameters
530			_aIssued also as CD
653		4	_aCisplatin-hepatorenal toxicity
653		4	_aOriginum majorana ethanolic extract
653		4	_aOxidative stress
700	0		_aAmany Ahmed Sayed , _eSupervisor
700	0		_aAmel Mahmoud Soliman , _eSupervisor
700	0		_aMohamed Marzouk Mohamed , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSoheir _eCataloger
942			_2ddc _cTH
999			_c57681 _d57681