000			03174cam a2200349 a 4500
003			EG-GiCUC
005			20250223031546.0
008			160918s2016 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.11.07.Ph.D.2016.Ra.F
100	0		_aRabab fouad Mohamed
245	1	0	_aFibronectin gene polymorphisms in HCV related type II mixed cryoglobulinemia: risk of development of B-cell lymphoma / _cRabab fouad Mohamed ; Supervised Hala Farawela , Nariman M. Zahran , Bothaina Madkour
246	1	5	_aتعدد أشكال جين فيبرونكتن و مخاطر الأصابة بالليمفوما في مرضى الكريوجلوبولينيميا المختلطة في حالات مصابة بفيروس سي
260			_aCairo : _bRabab fouad Mohamed , _c2016
300			_a172 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
520			_aNHLs are clonal malignancies with diverse clinical presentations, pathogenesis and biologic behavior. It results from accumulation of genetic insults that lead to unregulated lymphocyte proliferation. Malignant lymphocytes usually accumulate in lymph nodes and cause the characteristic clinical feature of lymphadenopathy. HCV is a major cause of liver-related morbidity and is increasingly recognized as an instigator of B-cell lymphoproliferative disorders such as mixed cryoglobulinemia and non-Hodgkin lymphoma. Fibronectin is a multifunctional glycoprotein of 250 kDa which is encoded by a gene of over 75 kb in length, located on chromosome 2q34{u2013}36 and composed of 50 exons. The purpose of the current study was to investigate the possible relationship between two FN polymorphisms (called MspI and HaeIIIb) and the development of lymphoma in HCV positive patients with mixed cryoglobulinemic syndrome compared to healthy age and sex matched individuals. The present study included 75 patients; 25 HCV positive patients with MCns and 50 NHL patients, in addition to 25 healthy controls. To achieve this aim, genotyping for FN gene was done by PCR- RFLP technique and screening for HCV infection was performed by ELISA and confirmed by RT-PCR, cryoglobulins were detected by cold precipitation (4{u00B0}C for 72{u2013} 96 h) and plasma FN levels were assessed by ELISA. The study revealed that HaeIII-AB genotype can be considered as a risk factor for NHL development and high HaeIII-A allele frequency seems to be linked to NHL development. It was also found that plasma FN level did not show any significant difference between NHL patients and each of HCV positive patients with MCns and controls
530			_aIssued also as CD
653		4	_aFN gene polymorphisms
653		4	_aHCV
653		4	_aNHL
700	0		_aBothaina Madkour , _eSupervisor
700	0		_aHala Farawela , _eSupervisor
700	0		_aNariman Mohamed Zahran , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSoheir _eCataloger
942			_2ddc _cTH
999			_c57741 _d57741