000			03550cam a2200349 a 4500
003			EG-GiCUC
005			20250223031552.0
008			161004s2015 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.11.07.Ph.D.2015.Ol.C
100	0		_aOla Badr Metwally
245	1	0	_aCirculating hematopoietic derived fibrocytes in chronic hepatitis C patients with liver fibrosis / _cOla Badr Metwally ; Supervised Samia. H. Rizk , Nora E. I. Elbassiouni , Hassan A. A. Elgarim
246	1	5	_aدراسة مساهمة الخلايا الليفية المستمدة من الخلايا المكونة للدم في التليف الكبدي للمرضي المصابين بالتهاب الكبدي الفيروسي سي المزمن
260			_aCairo : _bOla Badr Metwally , _c2015
300			_a135 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
520			_aBackground: Chronic liver disease is a world wide common pathology characterized by an inflammatory and fibrotic process that may lead to progressive evolution from chronic hepatitis to cirrhosis. Bone marrow derived fibrocytes may play an important role in pathogenesis and resolution of liver fibrosis. These cells may offer new approaches for better understanding the pathogenesis of liver fibrosis. Aim of the work: We aim to define the proportion of circulating fibrocytes with hematopoietic progenitor origin as defined by CD45 and CD34 positivity and to assess whether they are increased in patients with chronic C hepatitis in correlation to the degree of liver fibrosis. Results: Data demonstrated a significant increase in the circulating levels of GM-CSF, TGF- Ý and Ü-SMA, along with a significant increased expression of CXCR4 in conjunction with a significant increase in the co expression of CD34, CD45 and collagen type I positive cells in different groups of patients compared to control group, denoting the presence of an increased proportion of circulating fibrocytes in peripheral blood of these patients. Data also revealed that the expression of CD34, CD45, collagen type I and CXCR4 positive fibrocytes, in peripheral blood, increased in step wise fashion in conjunction with worsening severity of liver disease. Conclusion: Our data showed a progressive increase of circulating fibrocytes in peripheral blood in patients with chronic liver disease which matched the advancement of the disease and the intensification of liver fibrosis. Liver fibrosis is associated with increased levels of circulating TGF-Ý1 and lipopolysaccharide, activation of myofibroblasts, and extensive deposition of extracellular matrix, mostly collagen Type I. TGF-Ý and LPS play a critical role in fibrogenesis and trigger fibrocyte recruitment to the injured liver promoting their differentiation into collagen type I producing myofibroblast, supporting that fibrocytes may become a novel target for anti fibrotic therapy
530			_aIssued also as CD
653		4	_aChronic liver diseases
653		4	_aFibrocytes
653		4	_aHepatitis C virus
700	0		_aHassan Ahmed A. Elgarim , _eSupervisor
700	0		_aNora E. I. Elbassiouni Ibrahim, _eSupervisor
700	0		_aSamia. Hassan Rizk , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSoheir _eCataloger
942			_2ddc _cTH
999			_c57930 _d57930