000			02306cam a2200349 a 4500
003			EG-GiCUC
005			20250223031554.0
008			161010s2016 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.08.07.Ph.D.2016.Re.P
100	0		_aRehab Ali Hussein Ali
245	1	0	_aPhytochemical and biological studies of Iris pseudacorous L. and trifolium alexandrinum L. cultivated in Egypt / _cRehab Ali Hussein Ali ; Supervised Seham Salah Eldin Elhawary , Nagwa Mohammed Ammar , Ali Mahmoud Elhalawany
246	1	5	_aدراسات فيتوكيميائية و بيولوجية لنباتى الايريس سوداكورس و الراتيفوليم الكسندرينم المنزرعة فى مصر
260			_aCairo : _bRehab Ali Hussein Ali , _c2016
300			_a381 , (21) P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy
520			_aIn the course of searching for new safe and effective hormone replacement therapies, the two plants Iris pseudacorus L. and Trifolium alexandrinum L. were selected in accordance to the previous reports of isoflavonoids possessing estrogenic activity isolated from related species. A bioassay guided study was conducted including in-vitro and in-vivo estrogenic assays for the isolation and the identification of active compounds. The polar extract of Trifolium alexandrinum L. aerial parts as well as the isolated luteolin-7-O-glucoside showed promising estrogenic activity in the in-vivo studies whereas the polar extract of Iris pseudacorus L. leaves showed potent estrogenic activity in the in-vitro study. The results are persuading to move forward in doing the clinical trials on human after accomplishing the required toxicity studies
530			_aIssued also as CD
653		4	_aEstrogenic activity
653		4	_aIris pseudacorus L.
653		4	_aTrifolium alexandrinum L.
700	0		_aAli Mahmoud Elhalawany , _eSupervisor
700	0		_aNagwa Mohammed Ammar , _eSupervisor
700	0		_aSeham Salah Eldin Elhawary , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aEnas _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c58006 _d58006