| 000 | 02936cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223031556.0 | ||
| 008 | 161016s2016 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.08.07.Ph.D.2016.Di.P | ||
| 100 | 0 | _aDina Mahmoud Abbas Elkersh | |
| 245 | 1 | 2 |
_aA Phytochemical and biological study of markhamia zanzibarica (bojer ex DC.) K. schum. cultivated in Egypt / _cDina Mahmoud Abbas Elkersh ; Supervised Fatma Salem Elsakhawy , M. M. Elmazar , Riham Salah Eldine Elsayed |
| 246 | 1 | 5 | _aدراسة فيتوكيميائيه و بيولوجيه لنبات مارخيميا زانزيباريكا (بوجر إكس دج.) ك. شام. المنزرع في مصر |
| 260 |
_aCairo : _bDina Mahmoud Abbas Elkersh , _c2016 |
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| 300 |
_a233 , 8 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy | ||
| 520 | _aAbstract Authentication and characterization of Markhamia zanzibarica (Bojer ex DC.) K. Schum through DNA fingerprint. The study of lipoidal matter of n-hexane extract of the unsaponifiable matter and fatty acid methyl ester of M. zanzibarica were analyzed using GC/MS. Isolation of oleanolic acid, ursolic acid, quadrangularic acid L and quadrangularic acid K from the chloroform fraction and isolation of 5,7,3`,5` tetrahydroxy flavanone, luteolin, Nigaichigoside F , luteolin-7-O-{uF062}-D-glucoside and apigenin-7-O-rutinoside from the ethyl 2 acetate fraction. Total steroidal content, total phenolic content and total flavonoid content were carried out on the total alcoholic extract and antioxidant assay using DPPH assay which was carried out on different extracts and fractions of aerial parts of Markhamia zanzibarica. The in vitro cytotoxic activity revealed that n- hexane extract was the most potent cytotoxic one on the HeLa cancer cell line while the Chloroform fraction was the most potent cytotoxic one on the MCF-7 cancer cell line. The in vitro estrogenic and anti-estrogenic activities revealed that the defatted alcoholic extract and the ethyl acetate fraction possessed estrogenic activity whereas the n-hexane extract and n-butanol fraction possessed anti-estrogenic activity. The study of lipoidal matter revealed presence of sterols in the n-hexane extract while the study of LC-MS/MS revealed presence of verbascoside compounds in the n-butanol fraction | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aDNA fingerprint | |
| 653 | 4 | _aGC/MS | |
| 653 | 4 | _aMarkhamia zanzibarica | |
| 700 | 0 |
_aFatma Salem Elsakhawy , _eSupervisor |
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| 700 | 0 |
_aMohamed Mohey Eldin Elmazar , _eSupervisor |
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| 700 | 0 |
_aRiham Salah Eldine Elsayed , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aSoheir _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c58084 _d58084 |
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