000 02633cam a2200325 a 4500
003 EG-GiCUC
008 161023s2016 ua dh f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aPh.D
099 _aCai01.11.18.Ph.D.2016.En.B
100 0 _aEnas Mostafa Mohamed Darwish
245 1 0 _aBiomarkers associated with increased risk of atherosclerosis in patients with Systemic Lupus Erythematosus and Antiphospholipid Syndrome /
_cEnas Mostafa Mohamed Darwish ; Supervised Aysha I. Z. Badawi , Alaa Abdelhamid , Mona Wasef
246 1 5 _aالدلالات المعملية المصاحبه لوجود تصلب الشرايين لدي مرضي الذئبة الحمراء و متلازمة الفوسفوليبيد
260 _aCairo :
_bEnas Mostafa Mohamed Darwish ,
_c2016
300 _a127 P. :
_bcharts , facsimiles ;
_c25cm
502 _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Internal Medicine
520 _aSystemic Lupus Erythematosus (SLE) is a chronic; usually life- long, potentially fatal autoimmune disease in which the immune system attacks various organs in the body. It occurs predominantly in women during reproductive age. SLE is characterized by multisystem microvascular inflammation with the generation of autoantibodies. It is also characterized by unpredictable exacerbations and remissions with various clinical manifestations. Antiphospholipid syndrome (APS) is a prothrombotic, systemic associated thrombosis and pregnancy morbidity. APS can occur as an isolated, primary condition or be associated with a connective tissue disorder such as systemic lupus erythematosus (SLE). Accelerated atherosclerosis (ATH) is more common and occurs much earlier in women with systemic lupus erythematosus (SLE) and it causes significant morbidity and mortality. Traditional risk factors do not fully explain the increased risk of cardiovascular disease, strongly suggesting that autoimmunity contributes to accelerated atherosclerosis. The aim of the research is to study the correlation between soluble TWEAK, serum leptin and the development of subclinical atherosclerosis in SLE patients and those with antiphosholipid syndrome
530 _aIssued also as CD
653 4 _aAntiphospholipid Syndrome
653 4 _aAtherosclerosis
653 4 _aSystemic Lupus Erythematosus
700 0 _aAlaa Abdelhamid ,
_eSupervisor
700 0 _aAysha Ibrahim Zakiy Eldin Badawi ,
_eSupervisor
700 0 _aMona Wasef ,
_eSupervisor
905 _aEnas
_eCataloger
905 _aNazla
_eRevisor
942 _2ddc
_cTH
999 _c58248
_d58248