| 000 | 03135cam a2200325 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 008 | 161026s2016 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.11.27.M.Sc.2016.Ma.S | ||
| 100 | 0 | _aMaha Emad Eldein Muhammad Hussein | |
| 245 | 1 | 0 |
_aStem cell evaluation by ALDH1A1 expression in ovarian epithelial tumors / _cMaha Emad Eldein Muhammad Hussein ; Supervised Ahmed Mahmoud Abdelaziz , Hala Naguib Hosni , Rasha Ahmed Khairy |
| 246 | 1 | 5 | _aتقييم الخلايا الجذعية بواسطة تعبير ايه ال دى اتش١ أ١ فى أورام المبيض الطلائية |
| 260 |
_aCairo : _bMaha Emad Eldein Muhammad Hussein , _c2016 |
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| 300 |
_a100 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pathology | ||
| 520 | _aBackground: Increasing evidence has proposed that tumors contain tumors initiating cells or cancer stem cells (CSCs) that are responsible for its progression and relapse. Aldehyde dehydrogenase 1A1 (ALDH1A1) has recently been identified as a marker for cancer stem cells in some human malignancies including ovarian epithelial cancer. Aim of Work: The assessment of immunohistochemical expression of ALDH1A1 in epithelial ovarian tumors, tracking stem cells during ovarian cancer development and its correlation with the clinicopathological features of such tumors. Methods: This study consisted of 42 cases of ovarian epithelial tumors, classified as 14 cases of benign cystadenomas, 14 cases of borderline tumors and 14 cases of carcinomas. Immunohistochemical reactions were carried out by using ALDH1A1 monoclonal antibody. Cases were classified into two groups, low ALDH1 expression and high ALDH1 expression. Results: Immunohistochemical staining of ALDH1A1 displayed a heterogeneous expression pattern, with differences in the distribution and intensity of positivity. High ALDH1 expression was detected in 26 cases (62%) out of the forty-two studied cases of ovarian tumors. The positivity of ALDH1 was significantly higher in the malignant tumors (86%) than in benign and borderline tumors (50%) (p value = 0.025). There was a significant correlation between ALDH1expression score and the tumor grade (p value = 0.05) where the highest expression of ALDH1 was detected among high grade tumors; grades II & III (100%). More expression of ALDH1A1 was noticed in cases with advanced stage but without statistically significant relation (P = 0.42). Highest ALDH1A1 expression was noticed in cases of serous type tumors (71%) and endometrioid type tumors (100%), although it doesn't reach statistical significance | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aALDH1A1 | |
| 653 | 4 | _aCancer stem cells | |
| 653 | 4 | _aOvarian epithelial tumors | |
| 700 | 0 |
_aAhmed Mahmoud Abdelaziz, _eSupervisor |
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| 700 | 0 |
_aHala Naguib Hosni, _eSupervisor |
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| 700 | 0 |
_aRasha Ahmed Khairy , _eSupervisor |
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| 905 |
_aNazla _eRevisor |
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| 905 |
_aShaima _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c58328 _d58328 |
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