000			03163cam a2200349 a 4500
003			EG-GiCUC
005			20250223031630.0
008			161224s2016 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.08.06.M.Sc.2016.Om.E
100	0		_aOmnia Mohamed Abdelaziz Hassan
245	1	0	_aEvaluation of avian influenza H5N1 plasmid-based inactivated Egyptian vaccine and treatment with antiviral drugs / _cOmnia Mohamed Abdelaziz Hassan ; Supervised Ali Mohamed Kholify Ahmady , Mohamed Abdelhaleem Ramadan , Mohammed Ahmed Ahmed Ali
246	1	5	_aالمنتج في مصر والعلاج بالعقاقيرالمضادة لهذا الفيروس H5N1تقييم فاعلية اللقاحات المعالجة جينيا والمحمولة علي البلازميد لأنفلونزا الطيور
260			_aCairo : _bOmnia Mohamed Abdelaziz Hassan , _c2016
300			_a105 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Microbiology and Immunology
520			_aAlthough several essential preventive and therapeutic strategies could help to combat severe IAV pandemics and epidemics, vaccination is still the primary defence line to combat IAV infection (Houser & Subbarao, 2015). Therefore, this work was designed to study the potency of plasmid-based H5N1 inactivated vaccine in controlling H5N1virus infection; and the antigenic variation as well as the cross-reactivity of the currently applied imported avian influenza vaccines. Besides, we performed a deliberate screening for the antiviral activity of commercial FDA approved antiviral drugs (acyclovir, ribavirin, amantadine HCl and Oseltamivir) to control H5N1infection. Moreover, some commercial disinfectants (Chlorine; 40.5 g/L and chloroxylenol; 4.8 W/V) were further investigated for their anti-septic activity in controlling avian influenza infection (H5N1). Herein, to determine the level of maternal antibodies (MA), 10 blood samples were collected randomly from 400 broiler chickens at days 1, 7, 10 and 14. Subsequently, sera were extracted and examined for their MA titer. After 2 weeks and waning of MA, experimental chickens were divided into 8 groups. Each group has received 0.5 ml of CEVAC vaccine intramuscular (IM),Re-5strainAI vaccine, ME FLUVAC vaccine, AI-VAC H5 vaccine, Kemiflu vak AI KV vaccine, and Re-1 strain AI vaccine, group was left as blank control, rg (M2583D)AI vaccine, respectively. The levels of raised antibodies in the sera of the vaccinated chicken were monitored with the hemagglutination inhibition assays using rg A/Duck/Egypt/M2383A/2010(H5N1, E3, rM2583A) as antigen
530			_aIssued also as CD
653		4	_aEgyptian
653		4	_aH5N1
653		4	_aPlasmid-based
700	0		_aAli Mohamed Kholify Ahmady , _eSupervisor
700	0		_aMohamed Abdelhaleem Ramadan , _eSupervisor
700	0		_aMohammed Ahmed Ahmed Ali , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSoheir _eCataloger
942			_2ddc _cTH
999			_c59143 _d59143