| 000 | 02592cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223031637.0 | ||
| 008 | 170109s2016 ua d f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.11.21.Ph.D.2016.Ne.S | ||
| 100 | 0 | _aNehad Samir Ali | |
| 245 | 1 | 0 |
_aSerum interleukin 6 and its relation to cognitive functions in elderly patients with early onset depression / _cNehad Samir Ali ; Supervised Abdelhamid Hashem Hashem Abdelhamid , Akmal Mostafa Kamal Hassan , Alia Adel Abdelfattah Saleh |
| 246 | 1 | 5 | _aالإنترلوكين 6 بالمصل وعلاقته بالوظائف المعرفية في كبار السن الذين يعانون من الإكتئاب ذي البداية المبكرة |
| 260 |
_aCairo : _bNehad Samir Ali , _c2016 |
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| 300 |
_a95 P. : _bcharts ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Neuropsychiatry | ||
| 520 | _aAdvancing age is known to be associated with disruption of homeostasis in the immune system. Although the effects of aging on immune function are poorly understood, the aging brain has been characterized by a shift in the homeostatic balance of inflammatory mediators observed in mid-adulthood .In the last decade, a body of evidence has consistently demonstrated an association between major depressive disorder (MDD) and cognitive impairment in elderly, especially in the domains of attention, working memory, and executive functions. Additionally, Immune status has also been associated with major depressive disorder (MDD) relative to healthy individuals. When the release of inflammatory cytokines is excessive or sustained, the inflammatory mediators predominantly, IL 6, have neurotoxic effects on neurons and glial cells.The effect of this immunologic shift on cognitive performance is unclear. Some longitudinal studies have indicated a relationship between high cytokine levels, e.g., interleukin-6 (IL-6) and C-reactive protein (CRP), in peripheral plasma and development of multiple forms of dementia | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aCognitive functions | |
| 653 | 4 | _aEarly Onset Depression | |
| 653 | 4 | _aInterleukin 6 | |
| 700 | 0 |
_aAbdelhamid Hashem Hashem Abdelhamid , _eSupervisor |
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| 700 | 0 |
_aAkmal Mostafa Kamal Hassan , _eSupervisor |
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| 700 | 0 |
_aAlia Adel Abdelfattah Saleh , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aShaima _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c59371 _d59371 |
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