| 000 | 02442cam a2200325 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 008 | 170122s2016 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.11.03.M.Sc.2016.Ma.A | ||
| 100 | 0 | _aMarwa Mohamed Abdelhamid | |
| 245 | 1 | 0 |
_aAnalysis of genetic association of angiotensin-converting enzyme gene with multiple sclerosis / _cMarwa Mohamad Abdelhamid ; Supervised Salwa Fayez Hasan , Marwa Farghali Ahmed , Rania Elsayed Hussein |
| 246 | 1 | 5 | _aتحليل الارتباط الجيني بين جين الانزيم المحول للأنجيوتنسين و مرض التصلب المتعدد بالجهاز العصبي |
| 260 |
_aCairo : _bMarwa Mohamed Abdelhamid , _c2016 |
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| 300 |
_a98 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Medical Biochemistry | ||
| 520 | _aBackground: Increased activity of angiotensin-converting enzyme (ACE) in the blood and cerebrospinal fluid of patients with multiple sclerosis (MS) suggested that ACE may play a role in the pathogenesis and progression of MS. Objectives: To assess the relation between ACE gene I/D polymorphism and prevalence of MS in Egyptian patients and to investigate its possible association with disease severity and progression. Also to assess the relation between TNF-Ü and MS.Subjects and Methods: This study was conducted on 60 MS patients and 50 healthy controls. Polymerase chain reaction (PCR) was applied to detect ACE gene I/D polymorphism. TNF-Ü levels were measured by ELISA.Results: There was no statistical significant difference in the distribution of ACE I/D genotypes (p = 0.115) or in the allelic frequencies (p = 0.067) between patients with MS and control subjects. Also, there was no statistical significant difference in TNF-Ü levels between MS patients and control (p=0.113). Conclusion: There is no relation between ACE I/D polymorphism and MS susceptibility and/or severity in the study population | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aACE gene | |
| 653 | 4 | _aMultiple sclerosis | |
| 653 | 4 | _aTNF-Ü | |
| 700 | 0 |
_aMarwa Farghali Ahmed , _eSupervisor |
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| 700 | 0 |
_aRania Elsayed Hussein , _eSupervisor |
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| 700 | 0 |
_aSalwa Fayez Hasan , _eSupervisor |
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| 905 |
_aEnas _eCataloger |
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| 905 |
_aNazla _eRevisor |
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| 942 |
_2ddc _cTH |
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| 999 |
_c59536 _d59536 |
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