000			02628cam a2200325 a 4500
003			EG-GiCUC
008			170123s2016 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.08.08.Ph.D.2016.Ah.P
100	0		_aAhmed Adel Katamesh Gebriel
245	1	2	_aA pharmaceutical study on a certain antibacterial drug for buccal application / _cAhmed Adel Katamesh Gebriel ; Supervised Magdy Ibrahim Mohamed , Ghada Ahmed Abdelbary , Amal Youssef M. Abdelreheem
246	1	5	_aدراسة صيدلية على عقار معين مضاد للبكتيريا للأستعمال بالفم
260			_aCairo : _bAhmed Adel Katamesh Gebriel , _c2016
300			_a260 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics
520			_aPeriodontitis is one of the most common diseases in Egypt more than 4000 years ago. No age group, ethnicity, gender or socio economic group is immune to it. According to the world oral health report, oral diseases is classified as major public health problems owing to their high prevalence and incidence all over the world. Severe periodontitis, which may result in tooth loss, is found in 5-15% of most populations. Periodontal diseases are more common in developing countries, due to oral health services is limited. Although bacterial resistance and adverse side effects of using systemic antibiotics, large doses of systemic antibiotics must be taken in periodontitis treatment to achieve sufficient concentrations in the gingival crevicular fluid of the periodontal pockets. Absence of topical antimicrobial periodontitis preparations in the Egyptian market makes systemic antibiotics the only available way for antibiotic treatment when needed. The aim of this study is to design and develop adequate antimicrobial preparations of tinidazole (TZ) for topical buccal application in periodontitis. Mucoadhesive lipid based drug delivery systems (LBDDS) e.g. (ethosomes, self microemulsion, and liquid crystals), mucoadhesive conventional gels and LBDDS based gels were developed and evaluated for their physical characters, invitro drug release
530			_aIssued also as CD
653		4	_aAntibacterial drug
653		4	_aLBDDS
653		4	_aPeriodontitis
700	0		_aAmal Youssef Mohamed Abdelreheem , _eSupervisor
700	0		_aGhada Ahmed Abdelbary , _eSupervisor
700	0		_aMagdy Ibrahim Mohamed , _eSupervisor
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c59571 _d59571