000			03125cam a2200325 a 4500
003			EG-GiCUC
008			170123s2016 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.27.M.Sc.2016.Ra.E
100	0		_aRabab Radi Gomaa Mahmoud
245	1	0	_aEvaluation of survivin expression in breast cancer : _bHistopathological and immunohistochemical study / _cRabab Radi Gomaa Mahmoud ; Supervised Solafa Ameen Alabyad , Hanan Hassan Mohammed , Rasha Ahmed Khairy
246	1	5	_aتقييم التعبير عن "سرفيفين" فى سرطان الثدي : _bدراسة هستوباثولوجية و كميائية هستومناعية
260			_aCairo : _bRabab Radi Gomaa Mahmoud , _c2016
300			_a165 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pathology
520			_aBackground: Breast cancer (BC) is the most common type of cancer among women world-wide and leading cause of cancer related deaths. As normal breast development is controlled by a balance between cell proliferation and apoptosis, and there is also strong evidence that tumor growth is not just a result of uncontrolled proliferation but also of reduced apoptosis. Tumor cells can acquire resistance to apoptosis by expression of certain anti {u2013} apoptopic proteins called Inhibitors of Apoptosis Proteins (IAP). Survivin is the smallest IAP family member and has a dual activity as both an inhibitor of apoptosis and regulator of cell cycle. Objectives: Investigation of immunohistochemical expression of survivin in cases of female BC and correlation of this expression with the clinico-pathological aspects of the tumors. Materials and methods: Fifty formalin fixed paraffin embedded BC tissue sections were randomly collected. All the available data were collected from the patients{u2019} reports. The paraffin blocks were sectioned and stained with hematoxylin & eosin stains for histologic evaluation. Additional sections were immunostained with survivin. Results: Nuclear survivin expression was detected in 66% of cases and it was associated with some of the negative prognostic factors although it didn't reach statistical significance (p-values were found to be higher than 0.05) where higher rate of survivin expression showed apparent direct association with IDC-NST histologic type, presence of insitu component, ER and PR negativity and high Ki-67 proliferation index as well as Her 2 enriched molecular subtype. Conclusion: Survivin expression is detected in 66% of breast carcinoma cases and is likely to be associated with poor prognosis making it a potential target for treatment
530			_aIssued also as CD
653		4	_aApoptosis
653		4	_aBreast cancer
653		4	_aImmunohistochemistery
700	0		_aHanan Hassan Mohammed , _eSupervisor
700	0		_aRasha Ahmed Khairy , _eSupervisor
700	0		_aSolafa Ameen Alabyad , _eSupervisor
905			_aEnas _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c59581 _d59581