000 02547cam a2200349 a 4500
003 EG-GiCUC
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008 170207s2016 ua h f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aPh.D
099 _aCai01.11.21.Ph.D.2016.Da.C
100 0 _aDalia Khalifa Zayet
245 1 0 _aCognitive impairment in schizophrenia and genetic expression of GABA using human induced pluripotent stem cells /
_cDalia Khalifa Zayet ; Supervised Mahmoud Elbatrawi , Hala Gabr , Heba Fathy Eid
246 1 5 _aالاضطراب المعرفى لمرضى الفصام و التعبير الجينى للجابا بإستخدام الخلايا الجذعية المتحوره المحفزة بواسطة الأنسان
260 _aCairo :
_bDalia Khalifa Zayet ,
_c2016
300 _a220 P. :
_bfacsimiles ;
_c25cm
502 _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Neuropsychiatry
520 _aNeurotransmitters in general and GABA in particular are very important in normal cognition and the alteration of GABergic neurotransmission is accused to be sharing in the cognitive impairment in schizophrenia. GABA is the main inhibitory neurotransmitter in the brain. Its role in cognitive functioning is mediated through its effect on neurodevelopment, on fast synaptic transmission and also on gamma band synchronization. Exploring the molecular changes and cellular genetic expression of GaBergic genes is an essential step to know more about the real functioning of GABA in patients presenting with schizophrenia. Measure the genetic expression of (GAD65), GAD67, GABA beta2 and (mGLUR7) in patients presenting with schizophrenia and finding possible correlation with cognitive functions. Modeling of schizophrenia through human induced pleuripotent stem cells (hIPSc) through reprogramming of fibroblasts into hIPSc followed by neuronal differentiation. Real time PCR was used for measurement of genetic expression. Subtests of wechsler intelligence, trail A and B and rey ostrich test were used to assess cognitive functions
530 _aIssued also as CD
653 4 _aGAD 65
653 4 _aGenetic expression
653 4 _aHuman induced pluripotent stem cells
700 0 _aHala Gabr ,
_eSupervisor
700 0 _aHeba Fathy Eid ,
_eSupervisor
700 0 _aMahmoud Elbatrawi ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aSamia
_eCataloger
942 _2ddc
_cTH
999 _c59718
_d59718