000			02987cam a2200325 a 4500
003			EG-GiCUC
008			170227s2016 ua o f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.08.06.M.Sc.2016.Sh.E
100	0		_aShaimaa Moustafa Haikal
245	1	4	_aThe effect of treatment with mesenchymal stem cells on mice treated with collagen induced arthritis : _bPossible role of interleukin 4 / _cShaimaa Moustafa Haikal ; Supervised Magdy Ali Amin , Laila Ahmed Rashed , Nourtan F. Abdeltawab
246	1	5	_aتأثير العلاج بالخلايا الجذعية الوسيطة على الفئران المعالجه بالكولاجين المسبب لمرض التهاب المفاصل : _bالدور المحتمل للانترليوكين4
260			_aCairo : _bShaimaa Moustafa Haikal , _c2016
300			_a83 P. : _bphotographs ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Microbiology and Immunology
520			_aRheumatoid arthritis (RA) is a debilitating disease causing decreased quality of life. The disease affects primarily small joints of the hands and feet and is classified as a chronic autoimmune disorder. Mesenchymal stromal cells (MSCs) have been shown to exert immunosuppressive activity with the possibility for use in the treatment of RA. Similarly, interleukin (IL)-4 has been investigated as a possible RA treatment. Therefore, in the current study, we aimed to investigate the effect of combination therapy of bone marrow-derived MSCs (BM-MSCs) and IL-4 as a possible treatment of murine collagen-induced arthritis (CIA). We induced arthritis in Balb/c mice by intradermal injection of 100 æg of type II collagen (CII) at day 0 and 21 and mice were examined daily for the onset of clinical manifestations of arthritis. Mice were divided into four groups, first group received intravenous injection (i.v.) of MSCs only, second group received intraperitoneal injection (i.p.) of IL-4 only, and a third group received i.v. and i.p MSCs and IL-4 respectively. A fourth CIA control group received PBS after induction of arthritis. In addition, a fifth group of untreated mice served as healthy controls. After four weeks of treatment, we collected blood from each group and mice were sacrificed and synovial tissue was examined. RA was evident in CIA control group by histopathological examination of knee joints that showed erosions of articular cartilage, edema and influx of inflammation compared to healthy controls
530			_aIssued also as CD
653		4	_aCollage induced arthritis
653		4	_aMesenchymal stromal cells (MSCs)
653		4	_aRheumatoid arthritis (RA)
700	0		_aLaila Ahmed Rashed , _eSupervisor
700	0		_aMagdy Ali Amin , _eSupervisor
700	0		_aNourtan F. Abdeltawab , _eSupervisor
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c59994 _d59994