000 02534cam a2200337 a 4500
003 EG-GiCUC
005 20250223031657.0
008 170304s2016 ua d f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.08.08.M.Sc.2016.Ro.P
100 0 _aRofida Mohamed Saad Ahmed
245 1 0 _aPharmaceutical study on an insoluble drug /
_cRofida Mohamed Saad Ahmed ; Supervised Mohamed Ahmed Elnabarawi , Islam Ahmed Hamed Khalil
246 1 5 _aدراسة صيدلية على عقار شحيح الذوبان
260 _aCairo :
_bRofida Mohamed Saad Ahmed ,
_c2016
300 _a203 P. :
_bcharts ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics
520 _aRepaglinide is a fast acting insulinotropic agent with an insulin release profile that mimics that of physiological glucose-stimulated insulin release. It is used in the manage»ment of type 2 diabetes, controlling both postprandial blood glucose (BG) and fasting BG levels, thereby minimizing the risk of diabetes-associated complications. In this study, we selected repaglinide as a model drug due to its pH dependent poor aqueous solubility. Chapter Ї modification of solubility and dissolution profile of Repaglinide by using vesicle system. The aim of the work in this chapter was to formulate niosomes loaded with repaglinide and to evaluate the prepared formulations in order to choose the best achieved formula for further studies. Chapter ЇЇ modification of solubility and dissolution profile of repaglinide by using solid dispersion technique. The aim of the work in this chapter was to formulate solid dispersion of RPG and to evaluate the prepared formulations in order to choose the best achieved formula to improve the oral bioavailability of the drug and to obtain burst release of RPG. Chapter ЇЇЇ preparation and evaluation of oral disintegrating tablet of repaglinide as a single dose therapy. The aim of the work in this chapter was to formulate oral disintegrating tablets as a single dose therapy from the selected best achieved formulae
530 _aIssued also as CD
653 4 _aNiosomes
653 4 _aRepaglinide
653 4 _aSolid dispersion
700 0 _aIslam Ahmed Hamed Khalil ,
_eSupervisor
700 0 _aMohamed Ahmed Elnabarawi ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aSamia
_eCataloger
942 _2ddc
_cTH
999 _c60080
_d60080