000 02052cam a2200325 a 4500
003 EG-GiCUC
008 170315s2016 ua d f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.11.27.M.Sc.2016.Ri.C
100 0 _aRiham Farouk Gabr
245 1 0 _aChromogenic in situ hybridization (CISH) evaluation of human epidermal growth factor receptor 2 (HER 2) gene amplification in invasive duct carcinoma on tissue microarray TMA /
_cRiham Farouk Gabr ; Supervised Amira Mohamed Raafat , Samir Ahmed Shawky , Rasha Ahmed Khairy
246 1 5 _aتقييم اختبار التهجين الموضعى الملون فى البحث عن تضخيم جين الهير- تو فى حالات سرطان قنوات الثدى الغازى و ذلك باستخدام تقنية مصفوفة الأنسجة
260 _aCairo :
_bRiham Farouk Gabr ,
_c2016
300 _a105 P. :
_bcharts ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pathology
520 _aHuman epidermal growth factor receptor 2 (HER2) is an important predictive marker in invasive duct carcinoma (IDC), for selecting anti-HER2 therapy candidates. Forty six IDC cases were tested for HER2 amplification by chromogenic in situ hybridization (CISH) and immunohistochemistry (IHC) on a tissue microarray (TMA). A non cost manual method using pencil tips was used to construct two TMA blocks, where each case was represented by three cores. Comparing CISH and IHC results, it was found that there was 100% concordance between both tests in cases of IHC scores (+3,+1,0), and lesser concordance values in IHC equivocal +2 cases
530 _aIssued also as CD
653 4 _aCISH
653 4 _aHER 2
653 4 _aIDC
700 0 _aAmira Mohamed Raafat ,
_eSupervisor
700 0 _aRasha Ahmed Khairy ,
_eSupervisor
700 0 _aSamir Ahmed Shawky ,
_eSupervisor
905 _aNazla
_eRevisor
905 _aSamia
_eCataloger
942 _2ddc
_cTH
999 _c60272
_d60272