000			02852cam a2200325 a 4500
003			EG-GiCUC
008			170318s2016 ua d f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.07.M.Sc.2016.Ha.A
100	0		_aHala Ashraf Hosni Abdelaziz
245	1	0	_aAssociation of protein tyrosine phosphatase N22 (1858C/T) polymorphism with systemic lupus erythematosus in Egyptian children / _cHala Ashraf Hosni Abdelaziz ; Supervised Heba Allah M. E. Sharaf Eldin , Azza A. K. Elhamshary , Hany A. F. Elghobary
246	1	5	_aالعلاقة بين الاشكال المتعددة فى جين بى تى بى إن 22 سى 1858 تى فى حالات الذئبة الحمراء فى الاطفال المصريين
260			_aCairo : _bHala Ashraf Hosni Abdelaziz , _c2016
300			_a122 P. : _bcharts ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
520			_aSystemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease, characterized by the production of multiple autoantibodies, complement activation, and immune-complex deposition, resulting in tissue and organ damage. To assess the frequency and possible association of protein tyrosine phosphatase N22 c.C1858T SNP polymorphism with SLE in Egyptian children. Seventy five SLE children patients and Seventy five healthy subjects were tested for PTPN22 (C1858T) genotypes by TaqMan real time PCR, and routine laboratory data (CBC, urea, creatinine) were done. In this study, there was significant difference in PTPN22 rs2476601p.R620W (c.C1858T) genotypes and alleles frequency among cases and the control group. The frequency of CT genotype was higher in SLE cases 5/75 (6.7%) as compared to the control group 0/75 (0.0%) which is statistical significant (P=0.023).The TT genotype was absent in both cases and the control group. Regarding the risky mutant T allele frequency, it was found that T allele frequency was significantly increased in cases 5/150 (3.3%) than the control group 0/150 (0%) (p=0.024). Regarding clinical manifestations, it was found that 4/5 (80%) of patients with CT genotype had renal affection and 20/70(28.57%) with CC genotype had renal affection which is statistically significant (P=0.017), but there was no significant difference between PTPN22 CC and CT genotypes regarding other clinical manifestations
530			_aIssued also as CD
653		4	_ac.C1858T
653		4	_aPTPN22
653		4	_aSLE
700	0		_aAzza Abdelkadr Elhamshary , _eSupervisor
700	0		_aHany Ahmed Fouad Elghobary , _eSupervisor
700	0		_aHeba Allah Mohamed Ebrahim Sharaf Eldin , _eSupervisor
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c60279 _d60279