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003 EG-GiCUC
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008 170325s2016 ua d f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aPh.D
099 _aCai01.11.21.Ph.D.2016.Sa.V
100 0 _aSandra Wassim Rushdy Elseesy
245 1 0 _aVitamin D level and its relation to clinical features of major depressive disorder /
_cSandra Wassim Elseesy ; Supervised Tamer Ahmed Goueli , Akmal Mostafa Kamal , Mohamed Abdelfattah Khalil
246 1 5 _aمستوى فيتامين د فى الدم و علاقته بالخصائص الأكلينكية لإضطراب الأكتئاب الجسيم
260 _aCairo :
_bSandra Wassim Rushdy Elseesy ,
_c2016
300 _a213 P. :
_bcharts ;
_c25cm
502 _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Neuropsychiatry
520 _aVitamin D possibly helps in the regulation of neurotransmission, neuroprotection, and nerve growth factor synthesis. Therefore, a vitamin D deficiency might lead to inactivated receptors and a disruption to the pathway that may result in depression. To assess the relationship between serum level of vitamin D and clinical features of major depressive disorder including its severity, symptomatology, and cognitive dysfunction (memory and attention). Serum levels of 25- hydroxy vitamin D were measured with electo-chemiluminescence binding assay technique in 75 patients with major depressive disorder. The patients were recruited from Psychiatry and Addiction Hospital Kasr Al Ainy from the outpatient clinic. Patients were subjected to SCID, Hamilton depression scale, Mini-mental status examination, Wechsler memory subtests (story A and paired associate learning test), Benton visual retention test and Trail B test. 94.6% of patients had vitamin D deficiency (< 20 ng/ml); there was no significant correlation between levels of vitamin D and severity of depression according to HAM-D. Regarding depression symptoms there was a statistically significant difference (p= 0.032) between levels of vitamin D, being more deficient in the presence of genital symptoms (decreased libido and menstrual disturbances) and decreased concentration. There was also no statistically significant correlation between level of vitamin D and different psychometric tests (MMSE, trail B, story A, PALT and BVRT) although they were globally impaired. Major depressive disorder is strongly associated with vitamin D deficiency but no statistical significant correlation could be established between serum levels of vitamin D and severity of depression
530 _aIssued also as CD
653 4 _aDepression sever
653 4 _aMajor depressive disorder
653 4 _aVitamin D
700 0 _aAkmal Mostafa Kamal ,
_eSupervisor
700 0 _aMohamed Abdelfattah Khalil ,
_eSupervisor
700 0 _aTamer Ahmed Goueli ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aSamia
_eCataloger
942 _2ddc
_cTH
999 _c60388
_d60388