000			03191cam a2200349 a 4500
003			EG-GiCUC
005			20250223031708.0
008			170327s2016 ua h f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.08.08.M.Sc.2016.Ma.E
100	0		_aMarwa Gamal Ahmed Ahmed Elhennawy
245	1	4	_aThe effect of Ü1-antitrypsin deficiency and bacterial loads on the efficacy of chronic obstructive pulmonary disease pharmacotherapy in Egyptian patients / _cMarwa Gamal Ahmed Elhennawy ; Supervised Yosri Akl , Nirmeen A. Sabry , Ahmed Sherif Attia
246	1	5	_aانتيتريبسين و الاحمال الجرثومية على فعالية المعالجة الدوائية لمرض الانسداد الرئوى المزمن فى المرضى المصريين {u٢١٦٠}Ü تأثير نقص
260			_aCairo : _bMarwa Gamal Ahmed Ahmed Elhennawy , _c2016
300			_a118 P. : _bfacsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics
520			_aChronic obstructive pulmonary disease (COPD) is associated with slowly progressive airflow obstruction. Chronic obstructive pulmonary disease (COPD) is caused by the combination of smoking, genetic susceptibility and exacerbated by infection. The genetic cause of COPD is {uF061}1-antitrypsin (AAT) deficiency where the gene encoding this protein shows genetic polymorphisms increasing the complexity of COPD predisposing factors. In addition, the development of pulmonary infections with different bacterial species is associated with exacerbation of COPD. How the different genotypes when combined with different types and loads of bacterial infections could affect the outcome of COPD and its responsiveness to therapy remain unclear. This is especially true regarding Egyptian patients where COPD is widespread and at the same time genotyping of these patients is almost absent. Screen for the AAT deficiency alleles phenotypically and genotypically and hence assess the contribution of two of the most common deficiencies (Pi*S and Pi*Z) and two of the rare deficiencies alleles that were predicted to be prevalent in Egypt (Pi*Mmalton and Pi*Q0Cairo) in the development of COPD in Egypt. Compare this study results to the results collected in North African countries to study the mutation pattern in North Africa. Determine the effects of AATD on the efficacy of COPD conventional pharmacotherapy. Fifty-nine subjects (29 controls and 30 COPD patients) were tested for genetic AATD and respiratory function. The bacterial loads were determined to the patients{u2019} group who were then given a long acting beta-agonist and corticosteroid inhaler for 6 months
530			_aIssued also as CD
653		4	_aAAT deficiency
653		4	_aBacteria
653		4	_aChronic obstructive pulmonary disease
700	0		_aAhmed Sherif Attia , _eSupervisor
700	0		_aNirmeen Ahmed Sabry , _eSupervisor
700	0		_aYosri Akl , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c60437 _d60437