000			02858cam a2200349 a 4500
003			EG-GiCUC
005			20250223031717.0
008			170419s2016 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.18.M.Sc.2016.Sa.V
100	0		_aSamaa Ayman Anwar Saiid
245	1	0	_aVascular endothelial growth factor as a marker of hepatocellular carcinoma / _cSamaa Ayman Anwar Saiid ; Supervised Rokaya Abdelaziz Mohammed , Nagwa Ramadan Ahmed , Hala Gabr Metwally
246	1	5	_aعامل نمو بطانة الأوعية الدموية كعلامة عن سرطان الكبد
260			_aCairo : _bSamaa Ayman Anwar Saiid , _c2016
300			_a208 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine
520			_aBackground: Vascular endothelial growth factor (VEGF) is a secreted homodimeric cytokine and a primary driving force for both physiological and pathological angiogenesis, and its overexpression has been found in hepatocellular carcinoma (HCC). Furthermore, the invasiveness of certain HCC lesions has recently been linked to high levels of VEGF. So, in our study we investigated the relation between serum VEGF levels and diagnosis of hepatocellular carcinoma as well as assessment of prognosis in HCC patients. Methods Patients with hepatocellular carcinoma and liver cirrhosis were prospectively enrolled. Blood samples drawn at the day of inclusion in the study were assessed for VEGF content by an enzyme-linked immunosorbent assay. VEGF levels were correlated with the presence as well as severity of hepatocellular carcinoma. The diagnostic value of VEGF was investigated by uni- and multivariate Cox regression analyses.results 90 patients were enrolled. Subjects with hepatocellular carcinoma (HCC) showed elevated serum levels of VEGF as compared to healthy subjects (1930.9+1060 pg/ml vs. 283+162.5 pg/ml, P=0.000). Patients with intra abdominal lymphnodes (P{u200A}={u200A}0.011) and more than one focal lesion (P{u200A}={u200A}0.044) had higher VEGF levels than patients without these findings. Low VEGF levels were a parameter independently associated with longer overall survival (sensitivity (83.3%) and specificity (81.7%) in prediction of HCC, with cut off value (872.5)
530			_aIssued also as CD
653		4	_aHepatocellular carcinoma HCC
653		4	_aInternal Medicine
653		4	_aVascular endothelial growth factor VEGF
700	0		_aHala Gabr Metwally , _eSupervisor
700	0		_aNagwa Ramadan Ahmed , _eSupervisor
700	0		_aRokaya Abdelaziz Mohammed , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShaima _eCataloger
942			_2ddc _cTH
999			_c60690 _d60690