| 000 | 04377cam a2200349 a 4500 | ||
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| 003 | EG-GiCUC | ||
| 005 | 20250223031720.0 | ||
| 008 | 170506s2016 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.12.02.M.Sc.2016.Mo.C | ||
| 100 | 0 | _aMona Elsayed Badr Elsayed | |
| 245 | 1 | 0 |
_aClinical significance of Neutrophil gelatinase-associated lipocalin and Matrix metalloproteinase-9 in colorectal cancer / _cMona Elsayed Badr Elsayed ; Supervised Mervat Elsayed Mohammed , Mohamed Ali Eldesouky , Mohammed Diaa Eldeen Abdelmaksoud |
| 246 | 1 | 5 | _aا{uئإئ٧}ھ{ێښڙڙڈ̆{ێښږښښ̆{ێښڙڍڈ ̆ا{uئإؤئ}{uئإأأ}{uئإئأ}{uئإ٩ئ}{uئآئئ}{uئإ٩٤} {uئإؤئ}{uئإإ٠}{uئإإ٠}{uئآئئ}{uئإ٩٢}{uئإإإ}{uئإؤآ}{uئإ٨إ}{uئإؤئ}{uئآئئ}{uئإإ٦} ا{uئإؤئ}{uئإإ٤}{uئإءإ}{uئإ٩٧}{uئإ٩٢}{uئإأ٢} {uئإ٩١}{uئإ٨إ}{uئإؤئ}{uئإإ٨}{uئآئئ}{uئإ٩٨}{uئإءإ}و{uئإؤ٣}{uئآئئ}{uئإؤإ} {uئإ٩ئ}{uئآئئ}{uئإئأ}{uئإ٩٧}{uئآئئ}{uئإإ٨}{uئآئئ}{uئإآ٠} و ا{uئإؤئ}{uئإإ٤}{uئإ٨إ}{uئإ٩٧}{uئإءإ}{uئآئإ}{uئإؤأ}{uئإآ٢} {uئإإ٣}{uئآئئ}{uئإ٩٨}{uئإ٨إ}{uئإؤئ}{uئإإإ}{uئإ٩١}{uئإءإ}و{uئإ٩٧}{uئآئئ}{uئإإ٨}{uئآئئ}{uئإآ٠} -٩ {uئإؤ٣}{uئإئ٠} {uئإآ٣}{uئإءإ}ط{uئإ٨إ}ن ا{uئإؤئ}{uئإؤ٨}{uئإإإ}{uئإؤئ}{uئإإإ}ن ا{uئإؤئ}{uئإإ٤}{uئإآ٤}{uئإ٩٨}{uئإؤ٨}{uئآئئ}{uئإإ٤}{uئإئ٠} |
| 260 |
_aCairo : _bMona Elsayed Badr Elsayed , _c2016 |
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| 300 |
_a126 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry | ||
| 520 | _aPurposes: Neutrophil gelatinase-associated lipocalin (NGAL), a recently recognized protein that binds to Matrix metalloproteinase-9 (MMP9).There is growing evidence implicating that Neutrophil gelatinase{u2013}associated lipocalin and Matrix metalloproteinase-9 play a role in the development and progression of cancers. In this study, we investigated the role of NGAL and MMP-9 in the tumorigenesis and progression of Colorectal Cancer (CRC).We showed the correlation between the plasma levels of NGAL and MMP-9 in CRC, and also we studied the effect of treatment with chemotherapy and/or radiotherapy on plasma levels of NGAL and MMP-9 in human CRC. Methods: We used ELISA immunoassay to measure the levels of plasma NGAL and MMP-9 in a cohort consisting of colorectal cancer patients (n=50) and controls (n=30). Cases were assigned into 5 groups: Group 1(Control),Group 2 (Patients with early stages (I,II), who weren{u2019}t receive chemotherapy and /or radiotherapy), Group 3 (Patients with early stages (I,II), who were received chemotherapy and/ or radiotherapy, Group 4 (Patients with late stages (III, IV), who weren't receive chemotherapy and/or radiotherapy) and Group 5(Patients with late stages (III, IV), who were received chemotherapy and/ or radiotherapy).Results: Both NGAL and MMP-9 plasma levels were highly significantly elevated in all studied groups compared to control group (P<0.0001) but no significant differences in plasma levels of NGAL and MMP-9 were found between groups that received treatment with chemotherapy and /or radiotherapy and those not received, or between different stages (Tumor Nodes Metastases staging (TNM)) of CRC. In addition we found significant correlation between levels of NGAL and levels of MMP-9(P = 0.044). NGAL was positively correlated with MMP-9 (The correlation coefficient between NGAL and MMP-9 was 0.286).Conclusion: Our study suggested that NGAL and MMP-9 may be have screening role but not for prognosis of CRC Patients and they have no value in monitoring the effect of treatment with chemotherapy and/or radiotherapy on CRC patients | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aColorectal cancer | |
| 653 | 4 | _aMMP-9 | |
| 653 | 4 | _aNGAL | |
| 700 | 0 |
_aMervat Elsayed Mohammed , _eSupervisor |
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| 700 | 0 |
_aMohamed Ali Eldesouky , _eSupervisor |
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| 700 | 0 |
_aMohammed Diaa Eldeen Abdelmaksoud , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aEnas _eCataloger |
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| 905 |
_aNazla _eRevisor |
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| 942 |
_2ddc _cTH |
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| 999 |
_c60796 _d60796 |
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