000 02707cam a2200349 a 4500
003 EG-GiCUC
005 20250223031723.0
008 170513s2016 ua h f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aPh.D
099 _aCai01.08.07.Ph.D.2016.Ma.Q
100 0 _aMarwa Yehia Zakaria Elharirry
245 1 0 _aQuality control of some herbal preparations used in skin CARE /
_cMarwa Yehia Zakaria Elharirry ; Supervsied Seham Salah Eldin Elhawary , Kamilia Fouly Taha , Hala Mohamed Elhefnawy
246 1 5 _aمراقبة الجودة لبعض المنتجات العشبية المستعملة فى العناية بالبشرة
260 _aCairo :
_bMarwa Yehia Zakaria Elharirry ,
_c2016
300 _a237 P. :
_bfacsimiles ;
_c25cm
502 _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy
520 _aDeveloping a herbal antifungal formulation containing eruca and garlic oils against highly resistant dermatophytes (Malassezia fufur AUMC No. 5173, Microsporum canis bodin AUMC No. 5490 and Trichophyton mentagrophytes AUMC No. 5501. 5501) and assessment of garlic oil thiosulfinates during the ex vivo percutaneous permeation through albino rat skin. Assay of antifungal activity was performed by filter paper disc method and agar well diffusion method. The components of volatile constituents and fixed oil of eruca seeds were studied using GC/MS. Thiosulfinates in garlic oil were analyzed by HPLC/UV. Both oils were incorporated into hair cream using span 60 and brij 58 at three different concentrations (2, 4 and 6% w/w) and alliin was ex vivo evaluated using albino rat skin mounted on Franz diffusion cells. The two oils have a synergistic effect on the first and additive effect on the second and the third fungi. The main constituents in eruca are 4-(methyl thio) butyl isothiocyanate (82%) for volatile constituents and erucic acid (40%) for the fixed one. The highest flux for alliin (0.337 ± 0.0015 mg/cm2/hr) was obtained at 4% surfactant concentration. Combination of oils has a high activity on the selected dermatophytes. Formulation of a herbal hair cream using span 60 and Brij 58 with a concentration 4% gives the highest permeation rate for alliin in garlic oil
530 _aIssued also as CD
653 4 _aDermatophytes
653 4 _aEruca
653 4 _aGarlic
700 0 _aHala Mohamed Elhefnawy ,
_eSupervisor
700 0 _aKamilia Fouly Taha ,
_eSupervisor
700 0 _aSeham Salah Eldin Elhawary ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aSamia
_eCataloger
942 _2ddc
_cTH
999 _c60880
_d60880