000			03018cam a2200325 a 4500
003			EG-GiCUC
008			170613s2016 ua f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.08.05.M.Sc.2016.Fa.D
100	0		_aFatma Elzhraa Mohammed Khaled Mohammed
245	1	0	_aDevelopment and validation of analytical methods for the determination of some fluoroquinolones / _cFatma Elzhraa Mohammed Khaled Mohammed ; Supervised Ramzia Ismail Elbagary , Marwa Ahmed Fouad , Emad Mohamed Hussien
246	1	5	_aطرق تحليلية لتقدير بعض الفلوروكينولونات و التحقق من صحتها
260			_aCairo : _bFatma Elzhraa Mohammed Khaled Mohammed , _c2016
300			_a220 P. ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry
520			_aDifferent methods for the determination of some fluoroquinolones, in pure form, in binary mixtures, in the presence of their degradation products and in pharmaceutical preparations, have been developed in this thesis. These drugs are ciprofloxacin hydrochloride, moxifloxacin hydrochloride and ofloxacin. Chromatographic part included the determination of (ciprofloxacin Hydrochloride and dexamethasone sodium phosphate), (ofloxacin and dexamethasone sodium phosphate), (moxifloxacin hydrochloride and dexamethasone sodium phosphate) and (ofloxacin and cefixime trihydrate) in pure form, in binary mixtures and in the presence of their acid degradation products, using high performance liquid chromatography. Spectrophotometric part included the determination of (moxifloxacin hydrochloride and ketorolac tromethamine) in binary mixture, using derivative spectrophotometry, in addition to a spectrophotometric method for the determination of (ciprofloxacin hydrochloride) in the presence of (dexamethasone sodium phosphate) and a derivative ratio spectrophotometric method for the determination of (ciprofloxacin hydrochloride and dexamethasone sodium phosphate) in binary mixture. Moreover, a derivative of ratio spectrophotometric method for the determination of (ofloxacin and dexamethasone sodium phosphate) in binary mixture and in the presence of ofloxacin acid degradation product. also, spectrophotometric part includes two spectrofluorimetric methods for the determination of (ciprofloxacin hydrochloride) and (moxifloxacin hydrochloride) in the presence of (dexamethasone sodium phosphate). Statistical comparison between the results obtained by the proposed methods and the official or reported methods was carried out
530			_aIssued also as CD
653		4	_aCiprofloxacin
653		4	_aMoxifloxacin
653		4	_aOfloxacin
700	0		_aEmad Mohamed Hussien , _eSupervisor
700	0		_aMarwa Ahmed Fouad , _eSupervisor
700	0		_aRamzia Ismail Elbagary , _eSupervisor
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c61183 _d61183