| 000 | 02849cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223031732.0 | ||
| 008 | 170613s2016 ua d f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.08.03.M.Sc.2016.Yo.A | ||
| 100 | 0 | _aYosra Zakaria Sewilam | |
| 245 | 1 | 0 |
_aAnalytical study on some drugs used in treatment of CNS disorders / _cYosra Zakaria Sewilam ; Supervised Soheir Abdelfattah Weshahy , Nagiba Yehia Hassan , Maha Abdelmonem Hegazy |
| 246 | 1 | 5 | _aدراسة تحليلية على بعض الأدوية المستخدمة فى علاج أمراض الجهاز العصبى المركزى |
| 260 |
_aCairo : _bYosra Zakaria Sewilam , _c2016 |
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| 300 |
_a263 P. : _bcharts ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry | ||
| 520 | _aMulticomponent pharmaceutical formulations have gained a lot of importance due to greater patient acceptance as a result of reduced pill burden, increased potency and multiple actions. Accordingly, estimation of drugs in combination therapy simultaneously is an important part in the field of pharmacy as it saves time of separation and yields accurate and precise results. As most pharmaceutical compounds are subjected to degradation which results in change in their activity, stability-indicating assay methods were developed for the selective determination of the intact drug in the presence of its degradation product. In this study different analytical techniques were applied for analysis of some CNS acting drugs either in combination or in the presence of their degradates. The chosen drugs are namely entacapone, bromazepam, levodopa and carbidopa. The aim of the work was to develop accurate, economic and selective methods for the analysis of the chosen drugs simultaneously in combination dosage forms and without interference from their degradates and to investigate the stability of the studied drugs according to ICH guidelines by exposing it to different stress conditions followed by developing stability indicating assay methods for the analysis of the active ingredient in presence of its degradation product. The proposed methods were simple, accurate, and reproducible, which would be feasible and sensitive for the determination of the studied drugs and were validated according to ICH-guideline | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aBromazepam | |
| 653 | 4 | _aEntacapone | |
| 653 | 4 | _aLevodopa | |
| 700 | 0 |
_aMaha Abdelmonem Hegazy , _eSupervisor |
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| 700 | 0 |
_aNagiba Yehia Hassan , _eSupervisor |
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| 700 | 0 |
_aSoheir Abdelfattah Weshahy , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aSamia _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c61191 _d61191 |
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