000 04499cam a2200349 a 4500
003 EG-GiCUC
005 20250223031736.0
008 170617s2016 ua dh f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.08.06.M.Sc.2016.Sa.R
100 0 _aSamira Zakaria Ahmed
245 1 0 _aRtrospective and prospective study of the Interrelation between Interleukin-28B and Endogenous Interferon Gamma in human infected with Hepatitis-C Virus and/or Schistosoma mansoni /
_cSamira Zakaria Ahmed ; Supervised Magdy Ali Amin , Samuel T. Melek , Nourtan F. Abdeltawab
246 1 5 _aدرا{uئإآ٣}{uئإ٩٤} ا{uئإآ٣}{uئإ٩٨}{uئإؤأ}{uئإآ٨}{uئإ٨إ}{uئإؤ٣}{uئآئئ}{uئإ٩٤} ذات ا{uئإ٩آ}{uئإءإ} ر{uئإ٩ئ}{uئإأأ}{uئإئ٢} {uئإؤئ}{uئإإ٠}{uئإأأ}{uئإئأ}{uئإؤ٧}{uئإ٩٤} {uئإ٩١}{uئآئئ}{uئإإ٦} ا{uئإئآ}{uئإإ٧}{uئإ٩٨}{uئإءإ}{uئإؤئ}{uئآئئ}{uئإإإ}{uئإؤآ}{uئآئئ}{uئإإ٦} ٢٨-{uئإ٩١}{uئإئ٢} وا{uئإئآ}{uئإإ٧}{uئإ٩٨}{uئإءإ}{uئإؤ٣}{uئآئئ}{uئإءإ}ون {uئإ٩ئ}{uئإ٨إ}{uئإإ٣}{uئإ٨إ} ذا{uئإ٩٧}{uئإئ٢} ا{uئإؤئ}{uئإإ٤}{uئإإ٨}{uئإآ٨}{uئإ٨٤} {uئإؤ٣}{uئإئ٢} ا{uئإؤئ}{uئإإ٤}{uئإءإ}{uئإآئ}{uئإئ٠} ا{uئإؤئ}{uئإإ٤}{uئإآأ}{uئإ٨إ}{uئإ٩١}{uئآئئ}{uئإإ٦} {uئإ٩١}{uئإؤ٤}{uئآئئ}{uئإءإ}وس ا{uئإؤئ}{uئإ٩٨}{uئآءؤ}{uئإ٨إ}ب ا{uئإؤئ}{uئإؤأ}{uئإ٩٢}{uئإءء} ا{uئإؤئ}{uئإإإ}{uئإ٩١}{uئإ٨إ}{uئإ٨آ}{uئإئ٢} ({uئإآ٣}{uئإئ٢}) ا{uئإؤئ}{uئإإ٤}{uئإآأ}{uئإ٨إ}{uئإء٣}{uئإ٩٠} أو {uئإأئ}{uئآئئ}{uئإءإ} ا{uئإؤئ}{uئإإ٤}{uئإآأ}{uئإ٨إ}{uئإء٣}{uئإ٩٠} {uئإؤئ}{uئإئء}{uئإآآ}{uئإ٨إ}{uئإ٩١}{uئإ٩٤} {uئإ٩١}{uئإ٩٢}{uئإإ٠}{uئآءؤ}{uئإ٨إ}رسيا المستقيم
260 _aCairo :
_bSamira Zakaria Ahmed ,
_c2016
300 _a104 P. :
_bcharts , facsimils ;
_c25 cm
502 _aThesis (M.Sc.) - Cairo University -Faculty of Pharmacy - Department of Microbiology and Immunology
520 _aIntestinal schistosomiasis and hepatitis C viral (HCV) infections are endemic in Egypt with the highest prevalence worldwide. Co-infections are common in Egypt leading to severe liver diseases. Several studies have been concerned with the characterization of immune responses in S. mansoni/HCV co-infection in relation to treatment. The different natures of viral and parasitic infections have raised questions on how the immune system combats HCV/S. mansoni co-infection. Thus, many studies were undergone to address this particular question. Although studies on genetic polymorphism in interleukin 28B (IL-28B) gene had shown promising results in predicting a HCV patient{u2019}s response to antiviral therapy, IL-28B plasma levels role in treatment-naïve chronic co-infection is still not clear. Therefore, a case-control study was performed to investigate the behaviour and correlation between IL-28B and gamma interferon (IFN-Þ), two distinguished immune markers in both HCV and S. mansoni infections. The study included a total of 126 patients recruited from Cairo and Nile Delta attending Kasr Al-Aini Hospital, Cairo, Egypt 2012{u2013} 2014. Subjects (n = 107) meeting our inclusion criteria, 57% from Cairo and 43% from Nile Delta, were divided to three groups; treatment-naïve chronic HCV-4 patients (n = 50), S. mansoni/HCV co-infected patients (n = 22) and healthy controls (n = 35). Clinical history and liver function markers were determined for each participant. Plasma levels of IL-28B and IFN-Þ were assayed for all participants by ELISA. HCV viral load was quantified using Real-Time PCR. In addition, plasma anti-schistosoma antibody titers were assayed along with rectal snips and microscopic stool examination for identification of viable S. mansoni viable eggs in feces
530 _aIssued also as CD
653 4 _aco-infection
653 4 _aHepatitis C virus
653 4 _aSchistosoma mansoni
700 0 _aMagdy Ali Amin ,
_eSupervisor
700 0 _aNourtan F. Abdeltawab ,
_eSupervised
700 0 _aSamuel T. Melek ,
_eSupervised
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aShimaa
_eCataloger
942 _2ddc
_cTH
999 _c61331
_d61331