000			03163cam a2200325 a 4500
003			EG-GiCUC
008			170708s2016 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.11.36.Ph.D.2016.Mo.C
100	0		_aMostafa Mahmoud Elkholy
245	1	0	_aCognitive dysfunction in children with benign childhood epilepsy with centrotemporal spikes : _bAn event related EEG desynchronization and synchronization study / _cMostafa Mahmoud Elkholy ; Supervised Hanan Hosny Abdelalim , Mona Abdelmoneim Nada , Neveen Mohammed Elfayoumy
246	1	5	_aالخلل الإدراكى لدى الأطفال المصابين بالصرع البؤرى الحميد : _bدراسة للتغيرات الحادثة لرسم المخ و المرتبطة بحدث ما
260			_aCairo : _bMostafa Mahmoud Elkholy , _c2016
300			_a175 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Neurophysiology
520			_aBackground: Children with benign childhood epilepsy with centro-temporal spikes (BCECTS) are at risk for cognitive impairment, but reliable methods, other than neuropsychological testing, to verify such a decline are few. Objective: The aim of our work is to study quantitative analysis of the brain responses to cognitive tasks using event related desynchronization (ERD) and event related synchronization (ERS) and correlate the results with cognitive dysfunction in our patients. Methods: Our study included 50 children (30 patients and 20 matched healthy controls). Clinical assessment, Neuropsychological tests, Behavioral measures, P300 averaging and Quantitative EEG analysis were carried out for the patients and control groups, in addition to brain imaging (MRI or CT scan) for the patients` group. Alpha power ERD and ERS were measured as the percent decrease or increase in alpha power produced by target tones relative to reference intervals in six different brain regions during an auditory oddball paradigm. Results: Epileptic children showed statistically significant poorer cognitive performance in the neuropsychological and behavioral tests (verbal IQ, performance IQ, letter cancellation test and the number of correct responses). Moreover, both groups showed diffuse alpha power attenuation in response to the target tones, however this alpha power ERD was significantly smaller in the epileptic children compared to the healthy group. No significant P300 wave latency or amplitude difference between groups and no significant correlation between the alpha ERD percentage and neuropsychological results were found
530			_aIssued also as CD
653		4	_aAlpha event related desynchronization synchronization
653		4	_aBenign childhood epilepsy with centrotemporal spikes
653		4	_aCognitive dysfunction
700	0		_aHanan Hosny Abdelalim , _eSupervisor
700	0		_aMona Abdelmoneim Nada , _eSupervisor
700	0		_aNeveen Mohammed Elfayoumy , _eSupervisor
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c61491 _d61491