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003 EG-GiCUC
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008 170729s2014 ua f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aGift
097 _aM.Sc
099 _aCai01.34.M.Sc.2014.Sa.N
100 0 _aSamy Abdalla Mehany Habib
245 1 0 _aN{u2160}-linked metatonin dimers as bivalent ligands targeting dimeric melatonin receptors /
_cSamy Abdalla Mehany Habib ; Supervsied Darius P. Zlotos
246 1 5 _aكمركبات ثنائية التكافؤ تستهدف مستقبلات الميلاتونين المثنوية N{u2160}- مركبات ميلاتونين ثنائية الوحدات مرتبطة عن طريق
260 _aCairo :
_bSamy Abdalla Mehany Habib ,
_c2014
300 _a118 Leaves ;
_c30cm
502 _aThesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceulical Chemistry
520 _aThe diverse physiological actions of the pineal neurohormone melatonin are mainly mediated through activation of two G-protein-coupled receptors MT₁, and MT₂. These receptors are known to form homo-and heterodimers with distinct functions and properties opening new perspectives for drug design and drug treatment. The bivalent ligand approach is a common strategy for targeting dimeric GPCRs
653 4 _aDimeric melatonin receptors
653 4 _aN{u2160}-linked metatonin dimers
653 4 _aTargeting dimeric GPCRs
700 0 _aDarius P. Zlotos ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aSamia
_eCataloger
942 _2ddc
_cTH
999 _c61690
_d61690