| 000 | 03159cam a2200349 a 4500 | ||
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| 003 | EG-GiCUC | ||
| 005 | 20250223031800.0 | ||
| 008 | 170823s2017 ua do f m 000 0 eng d | ||
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_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.08.09.Ph.D.2017.Ma.S | ||
| 100 | 0 | _aMai Amin Kamel Zaafan | |
| 245 | 1 | 0 |
_aStudy of the possible effect of pyrrolidine dithiocarbamate and hesperidin on experimentally induced pulmonary fibrosis / _cMai Amin Kamel Zaafan ; Supervised Sanaa A. Kenawy , Amany I. Elbrairy , Hala F. Zaki |
| 246 | 1 | 5 | _aدراسة التأثير المحتمل لبيروليدين داى ثيو كاربامات و هسبيردين فى التليف الرئوى المحدث تجريبيا |
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_aCairo : _bMai Amin Kamel Zaafan , _c2017 |
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| 300 |
_a121 P. : _bcharts , photographs ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology | ||
| 520 | _aPulmonary fibrosis is a chronic progressive and ultimately fatal lung disease. It is characterized by epithelial cell apoptosis, fibroblast proliferation and abnormal accumulation of extracellular matrix molecules, particularly collagen. Objective: The current study aimed to investigate the modulatory effects of pyrrolidinedithiocarbamate (PDTC; 100 mg/kg) and hesperidin (200 mg/kg) on bleomycin-induced pulmonary fibrosis (5 mg/kg; intratracheal) in rats. Materials and methods: Rats were randomly assigned to three groups: normal control, bleomycin control, PDTC-treated and hesperidin-treated groups. Lung injury was evaluated through histological examination, immunohistochemical detection of inducible nitric oxide synthase (iNOS) in lung tissue and evaluating the total and differential leucocytes count in bronchoalveolar lavage fluid. Lung tissue was used for biochemical assessment of lung content of hydroxyproline, transforming growth factor beta-1 (TGF-Ý1), tumor necrosis factor-alpha (TNF-Ü) as well as analysis of lipid peroxides, reduced glutathione (GSH), and total nitrite contents. Results: PDTC and hesperidin attenuated bleomycin-induced pulmonary fibrosis as evidenced by histological observations, decreased iNOS expression and prevention of bleomycin-induced altered total and differential leukocytes count. Additionally, PDTC and hesperidin caused a significant decrease in lung contents of hydroxyproline, TGF-Ý1, TNF-Ü, lipid peroxides, and total nitrite coupled with increase in lung GSH content as compared to bleomycin control group. Conclusion: PDTC and hesperidin attenuated bleomycin-induced pulmonary fibrosis in rats via its anti-inflammatory, antioxidant, and antifibrotic activities | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aHesperidin | |
| 653 | 4 | _aPulmonary fibrosis | |
| 653 | 4 | _aPyrrolidinedithiocarbamate | |
| 700 | 0 |
_aAmany Ibrahim Elbrairy , _eSupervisor |
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| 700 | 0 |
_aHala Fahmy Zaki , _eSupervisor |
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| 700 | 0 |
_aSanaa Abdelbaky Kenawy , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
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_aNazla _eRevisor |
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| 905 |
_aSamia _eCataloger |
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_2ddc _cTH |
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_c62119 _d62119 |
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