000			03227cam a2200337 a 4500
003			EG-GiCUC
005			20250223031802.0
008			170905s2016 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.09.13.M.Sc.2016.No.I
100	0		_aNoura Mohamed Kamal Eldin Mohamed Aly
245	1	0	_aImmunohistochemical expression of epcam in mucoepidermoid carcinoma and solid variant of adenoid cystic carcinoma compared to normal salivary gland tissues : _bObservational study / _cNoura Mohamed Kamal Eldin Mohamed Aly ; Supervised Hend Mohammad Waguih Mahmoud Salem , Heba Mahmoud Dahmoush
246	1	5	_a في سرطان مخاطية بشروية و النوع الصلب من سرطان غدانية كيسية مقارنة مع أنسجة الغدة اللعابية الطبيعية EpCAM تعبيرمناعي : _bدراسة وصفية
260			_aCairo : _bNoura Mohamed Kamal Eldin Mohamed Aly , _c2016
300			_a127 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral and Maxillofacial Surgery
520			_aEvaluate the immunohistochemical expression of EpCAM in different grades of MEC and solid variant of adenoid cystic carcinoma (solid AdCC) in comparison with the normal salivary glands, to ascertain the possible prognostic significance and propose EpCAM targeted therapy as a possible treatment approach for patients with salivary gland tumors overexpressing this cell surface marker.Material and Methods: A total of 60 archival paraffin embedded specimens (12 normal salivary gland tissue, 36 MEC and 12 Solid AdCC) were collected and EpCAM expression was evaluated by immunohistochemistry. The total immunoscore (TIS) was evaluated, which represented the product of the proportion score (PS) and the intensity score (IS). The term {u2018}EpCAM overexpression{u2019} was given for tissues showing a total immunostaining score >4. Results: A highly significant difference was detected between TIS percent values in control, different grades of MEC and solid AdCC. In MEC, EpCAM expression increased in HG-MEC compared to IMG-MEC and LG-MEC (Pearson's chi square test, p < 0.01), but no significant difference was observed between LG-MEC and IMG-MEC (Pearson's chi square test, P> 0.05). Solid AdCC showed the highest TIS percent values in relation to different grades of MEC. HG-MEC and solid AdCC were found to be the highest EpCAM expressors (TIS>4). Although, lack of EpCAM expression was detected in 2 cases (16.7%) of HG-MEC and one case (8.3%) of solid AdCC. Conclusion: EpCAM was frequently detected in MEC and solid AdCC making these tumours potential targets for anti-EpCAM therapies
530			_aIssued also as CD
653		4	_aEpCAM
653		4	_aMucoepidermoid carcinoma and solid adenoid cystic carcinoma
653		4	_aOral and Maxillofacial Surgery
700	0		_aHeba Mahmoud Dahmoush , _eSupervisor
700	0		_aHend Mohammad Waguih Mahmoud Salem , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aEnas _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c62184 _d62184