000			02918cam a2200325 a 4500
003			EG-GiCUC
008			170910s2016 ua h f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.07.M.Sc.2016.Sa.U
100	0		_aSafaa Osama Algohary
245	1	0	_aUtility of quantiFERON-TB in-tube test for detection of latent tuberculosis (TB) in patients with hematological malignancies / _cSafaa Osama Algohary ; Supervised Amany Ali Elkholy , Hadir Ahmad Elmahalawy , Safaa Shawky Hassan
246	1	5	_aاستخدام اختبار الكوانتيفيرون للكشف عن مرض السل الكامن فى المرضى الذين يعانون من أمراض الدم الخبيثة
260			_aCairo : _bSafaa Osama Algohary , _c2016
300			_a109 P. : _bfacsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
520			_aBackground: Patients with immunodeficiency, such as those suffering from hematological malignancies, have alteration in the T-cell response either by the malignancy itself or that caused by antineoplastic chemotherapy which lead to an impaired immune response that particularly promotes the progression from LTBI to active TB. T-cell-based Interferon-Gamma (IFN-Þ) Release Assays (IGRAs) constitute a promising alternative to TST for diagnosing tuberculosis infection with higher sensitivity and specificity. Objectives: The aim of this study was to evaluate the role of quantiFERON-TB gold IT test in detection of latent tuberculosis infection in patients with hematological malignancies presenting to the National cancer institute as new cases and correlating the results with the different clinical and laboratory findings of the patients as well as the overall survival. This was done in order to help preventing the spread of this infection. Subjects and methods: The study was conducted on 52 unselected cases of newly diagnosed cancer patients who presented to the outpatient clinic at National cancer institute, Cairo university. Patients{u2019} data included age, sex, clinical manifestations of infection, laboratory data of the patients, chest radiological findings and the outcome after induction therapy. Cases were tested for latent TB using the quantiFERON-TB Gold IT test. Results: As regard the QFT we found that 9 cases out of 52 (17.5%) were positive for latent TB and 43 out of 52 (82.7%) were negative for QFT
530			_aIssued also as CD
653		4	_aHematological malignancies
653		4	_aImmunocompromised
653		4	_aLatent tuberculosis
700	0		_aAmany Ali Elkholy , _eSupervisor
700	0		_aHadir Ahmad Elmahalawy , _eSupervisor
700	0		_aSafaa Shawky Hassan , _eSupervisor
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c62236 _d62236