000			03049cam a2200349 a 4500
003			EG-GiCUC
005			20250223031803.0
008			170910s2017 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.29.M.Sc.2017.Ve.P
100	0		_aVeronia Fawzy Fahim
245	1	0	_aPossible memory protective role of simvastatin and insulin in a rat model of diabetes mellitus and dementia / _cVeronia Fawzy Fahim ; Supervised Amani Nabil Shafik , Magdy Ishak Attallah , Walaa Wadie Ibrahim
246	1	5	_aالدور الوقائى المحتمل لسيمفاستاتين و الإنسولين على الذاكرة فى نموذج البوال السكرى و الخرف التجريبى المحدث فى الجرذان
260			_aCairo : _bVeronia Fawzy Fahim , _c2017
300			_a161 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pharmacology
520			_aIntroduction: This study is an experimental study to investigate the possible memory protective role of insulin and simvastatin (at doses of 10 and 20 mg/kg/day) in a rat model of diabetes mellitus and dementia. Materials and methods: 100 healthy adult female albino rats weighing 200-250 gm were used and divided into two main groups. Group 1: control normoglycemic rats including 4 subgroups (10 rats/ each): Group 1a Untreated rats were left to the end of the experiment, Group 1b rats received volume of 0.5 ml (0.1 M) sodium citrate buffer single intraperitoneal injection, Group 1c rats received simvastatin 10 mg/kg/day by oral gavage and Group 1d rats received simvastatin 20 mg/kg/day by oral gavage. Group 2 Diabetic animals where DM was induced by a single intraperitoneal injection of streptozotocin (STZ) 60 mg/kg body weight. This group included 6 subgroups: Group 2a untreated rats, Group 2b Insulin treated rats, Group 2c Simvastatin treated rats in a dose of 10 mg/kg/day orally, Group 2d Simvastatin treated rats in a dose of 20 mg/kg/day orally, Group 2e Insulin+simvastatin (10 mg/kg/day) treated rats, Group 2f Insulin+simvastatin (20 mg/kg/day) treated rats. Treatment started after rise of blood glucose and continued for 6 weeks. To detect behavioral changes (long and short memory whether spatial or non-spatial), Morris water maze test was done 4 times; before induction of DM and every 2 weeks and Y maze test was held after 6 weeks at the end of the experiment. Serum samples were obtained from the retro-orbital sinus for measuring glucose, cholesterol and insulin levels
530			_aIssued also as CD
653		4	_aMemory deficits
653		4	_aMorris water maze test
653		4	_aSimvastatin
700	0		_aAmani Nabil Shafik , _eSupervisor
700	0		_aMagdy Ishak Attallah , _eSupervisor
700	0		_aWalaa Wadie Ibrahim , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c62244 _d62244