000			03306cam a2200349 a 4500
003			EG-GiCUC
005			20250223031805.0
008			170912s2016 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.11.21.Ph.D.2016.Lo.E
100	0		_aLobna Ahmed Talaat Elghoneimy
245	1	0	_aEvaluation of cognitive functions and Diffusion tensor imaging mri in patients With juvenile myoclonic epilepsy / _cLobna Ahmed Talaat Elghoneimy ; Supervised Iman Elbanhawy , Nermeen Adel , Kamel Hamouda
246	1	5	_aتقييم مرضي صرع الرجفة الفتياني للوظائف المعرفية بالرنين المغناطيسي موتر الانتشار
260			_aCairo : _bLobna Ahmed Talaat Elghoneimy , _c2016
300			_a174 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Medicine- Department of Neuropsychiatry
520			_aas been reported with significant impairment on tests of frontal functioning. The JME group had poor performance on tests requiring concept formation and mental flexibility, and had difficulties in focusing attention and inhibiting habitual response sets. Cognitive correlates of JME have received little attention despite the extensive studies of cognition in other types of epilepsy. Aim of work: Study the cognitive performance in patients with JME. Determine the relation between neuroanatomical/neurophysiological abnormalities, and epileptic clinical characteristics with the cognitive performance in patients with JME. Methods: Fifty patients with JME and a sample of healthy controls were assessed using a series of neuropsychological tests as well as diffusion tensor MRI (DTI) and tractography. DTI measures assessed fractional anisotropy (FA) within a white matter skeleton. Results: Cognitive testing indicated subtle dysfunction in verbal learning and memory, phonemic and semantic fluency, attention, speed and mental flexibility. Using white matter diffusion MRI data, we found reductions in FA in underlying white matter of the left anterior corpus callosum, right supplementary motor area and left anterior cingulate. Reduced FA in the left anterior corpus callosum predicted uncontrolled generalized tonic-clonic convulsions (GTCs). As well as reduced FA in the left anterior corpus callosum and left anterior cingulate predicted uncontrolled myoclonus. Conclusion: Patients with JME had lower cognitive performance in verbal learning and memory, attention, speed and mental flexibility, which was associated with white matter cortical/subcortical microstuctural alterations. Uncontrolled GTCs is an important predictor of lower cognitive performance between JME patients. As well as a cortical/subcortical alterations being a predicting factor for uncontrolled GTCs and Myoclonus
530			_aIssued also as CD
653		4	_aCognitive assessment
653		4	_aFractional anisotropy
653		4	_aJuvenile myoclonic epilepsy
700	0		_aIman Elbanhawy , _eSupervisor
700	0		_aKamel Hamouda , _eSupervisor
700	0		_aNermeen Adel , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c62301 _d62301