| 000 | 02636cam a2200337 a 4500 | ||
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| 003 | EG-GiCUC | ||
| 005 | 20250223031817.0 | ||
| 008 | 171002s2017 ua dbh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.13.03.Ph.D.2017.Es.H | ||
| 100 | 0 | _aEsraa Mamdouh Hashim Shabeb | |
| 245 | 1 | 0 |
_aHigh-حerformance system for detecting novel altered regions of Hepatocellular carcinoma using high-throughput sequencing / _cEsraa Mamdouh Hashim Shabeb ; Supervised Ayman M. Eldeib , Mai Mohamed S. Mabrouk |
| 246 | 1 | 5 | _aنظام عالي الأداء للكشف عن مناطق تغيرات جديده لسرطان الكبد الوبائي باستخدام تسلسل عالي الانتاجيه |
| 260 |
_aCairo : _bEsraa Mamdouh Hashim Shabeb , _c2017 |
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| 300 |
_a91 P. : _bcharts , maps, facsimiles ; _c30cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Engineering - Department of Systems and Biomedical Engineering | ||
| 520 | _a Hepatocellular carcinoma(HCC) is a tumor of the liver which usually arises in the setting of chronic liver diseases. Fibrolamellar hepatocellular carcinoma (F- HCC) is a rare entity of HCC not yet analyzed cytogenetically. The use of high- performance parallel computing techniques can enable researchers to employ large numbers of processors to run comprehensive analyses within a reasonable period. This work provides a genomic study that focuses on using bioinformatics approaches to predict the molecular causes of HCC and F-HCC by the investigation whole genome sequence of the chromosomal aberrations using single nucleotide polymorphism (SNP)arrays and Next generation sequence (NGS) by applying four statistical techniques. The study revealed 3 distinct structural variations related genes MDM4, PRDM5, and WHSC1, these genes are a novel target signature that can help to predict survival of patients with detecting F-HCC. A new altered chromosome region amplification(4q22.1), this altered chromosomal region is novel for detect HCC, this finding has not previously reported being involved in liver carcinogenesis. NGS detect EPHA5, UBE1L2 tumor suppressor and UGT2B28 for both F-HCC and HCC | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aHepatocellular carcinoma | |
| 653 | 4 | _aNext generation sequence | |
| 653 | 4 | _aWhole-genome sequencing | |
| 700 | 0 |
_aAyman M. Eldeib , _eSupervisor |
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| 700 | 0 |
_aMai Mohamed S. Mabrouk , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aShimaa _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c62688 _d62688 |
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