| 000 | 03644cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223031821.0 | ||
| 008 | 171007s2017 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.12.04.Ph.D.2017.As.P | ||
| 100 | 0 | _aAsmaa Sayed Elhoussiny | |
| 245 | 1 | 0 |
_aPreparation and characterization of biopolymeric nanoparticles as transdermal drug carriers for treatment of osteoarthritis on experimental animals / _cAsmaa Sayed Elhoussiny ; Supervised Wafaa Mohamed Ahmed Khalil , Kamal Nasr Abdelnour , Salwa Louis Abdelmessieh |
| 246 | 1 | 5 | _aتحضير وتوصيف بوليمرات نانومترية كحاملات ادوية من خلال الجلد لعلاج خشونة المفاصل على حيوانات التجارب |
| 260 |
_aCairo : _bAsmaa Sayed Elhoussiny , _c2017 |
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| 300 |
_a173 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biophysics | ||
| 520 | _a Glucosamine sulfate (GS) has been used orally for the treatment of osteoarthritis however it may be susceptible to liver first pass phenomenon which greatly affects its bioavailability in addition to its side effects on the gastrointestinal tract. The aim of this study is to apply nanoencapsulation technologies using gelatin (Gel) and alginate (Alg) nanoparticles (NPs) as a new vehicle for transdermal delivery of GS to improve its effectiveness and reduce side effects. The GS-Gel and GS-Alg NPs were characterized through percentage yield, encapsulation efficiency, transmission electron microscope (TEM), particle size (DLS), zeta potential, Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and dielectric spectroscopy. The in vitro release studies of GS and the ex vivo permeability through rat skin were determined using UV-VIS spectrophotometer. High drug encapsulation efficiency and nanoparticle yield were achieved for both Gel and Alg NPs. The TEM and DLS studies revealed that GS-Gel and GS-Alg NPs have small particle size in the nanometer size range. The zeta potential results indicated an initiation of electrostatic interaction occurred between GS, Gel and Alg NPs. FTIR studies showed a spectral change of the characteristic absorptions bands in both Gel and Alg NPs after encapsulation with GS. DSC data indicated changes in the thermal behavior of GS-Gel and GS-Alg NPs after the addition of GS. Furthermore, the dielectric study indicated an increase in the activation energy and the relaxation time of the 1st process in the GS-Gel and GS-Alg NPs suggesting the successful encapsulation of GS. The in vitro release studies showed that GS is released from Gel and Alg NPs in a sustained and prolonged manner. The ex vivo permeation of GS through rat skin increased for Gel NPs that contains 10% DMSO and enhanced significantly after encapsulation in the negatively charged Alg NPs. In this study, we successfully developed transdermal delivery nanosystem on an industrial scale using Gel and Alg NPs that permits the encapsulation of GS overcoming the disadvantages of oral administration | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aGelatin | |
| 653 | 4 | _aGlucosamine sulfate | |
| 653 | 4 | _aOsteoarthritis | |
| 700 | 0 |
_aKamal Nasr Abdelnour , _eSupervisor |
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| 700 | 0 |
_aSalwa Louis Abdelmessieh , _eSupervisor |
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| 700 | 0 |
_aWafaa Mohamed Ahmed Khalil , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aShimaa _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c62787 _d62787 |
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