| 000 | 02796cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223031826.0 | ||
| 008 | 171015s2017 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
||
| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.11.28.Ph.D.2017.Ma.L | ||
| 100 | 0 | _aMariam Saad Soliman Nassim | |
| 245 | 1 | 0 |
_aLiver iron concentration and serum hepcidin levels in patients with beta thalassemia / _cMariam Saad Soliman Nassim ; Supervised Ilham Youssry Ibrahim , Hadeel Mohammed Seif Eldein Aly , Rania Mohamed Samy Mohamed |
| 246 | 1 | 5 | _aمستوى الحديد بالكبد و مستوى الهبسيدين بالدم لدى مرضى انيميا البحر الابيض المتوسط |
| 260 |
_aCairo : _bMariam Saad Soliman Nassim , _c2017 |
||
| 300 |
_a179 P. : _bcharts , facsimiles ; _c25cm |
||
| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics | ||
| 520 | _aThe aim of this study was to assess serum hepcidin levels among transfusion and non transfusion dependent thalassemia patients, to radiologically evaluate iron level in different tissues, to find a correlation between serum hepcidin and the studied iron overload indices and to identify the risk factors of iron overload. Methods: Eighty six thalassemia patients (56 TDT and 30 NTDT) were all subjected to history taking, clinical examination, and laboratory testing including full blood picture, serum ferritin detected by enzyme linked fluorescent assay, serum hepcidin: detected by enzyme linked immunosorbent assay . HAMP gene polymorphisms were detected using PCR-RFLP technique. Thirty six patients had a liver MRI (15 NTDT and 22 TDT) in which the pancreas and adrenal glands were visualized in eighteen patients (12 TDT and 6 NTDT) and twenty one had a heart MRI (14 TDT and 7 NTDT). Results: In this study, mean serum hepcidin was higher among TDT patients than NTDT patients. Among our patients,16.6% did not have liver iron overload (LIC<2mg/kg dw), 38.8% had mild iron overload (LIC 2-6 mg/kg dw), and 44.4% had moderate to severe iron overload (LIC >6mg/kg dw). Out of 21 evaluated patients: 4.5% had severe cardiac siderosis (T2*<10ms), 4.5% had moderate cardiac siderosis (T2* 10-20ms) and 91% had no cardiac iron overload (T2*>21ms). 61% of the studied patients demonstrated pancreatic T2*<21ms | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aHepcidin | |
| 653 | 4 | _aNTDT | |
| 653 | 4 | _aTDT | |
| 700 | 0 |
_aHadeel Mohammed Seif Eldein Aly , _eSupervisor |
|
| 700 | 0 |
_aIlham Youssry Ibrahim , _eSupervisor |
|
| 700 | 0 |
_aRania Mohamed Samy Mohamed , _eSupervisor |
|
| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
||
| 905 |
_aSamia _eCataloger |
||
| 942 |
_2ddc _cTH |
||
| 999 |
_c62960 _d62960 |
||