000			02920cam a2200349 a 4500
003			EG-GiCUC
005			20250223031830.0
008			171022s2017 ua d f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.28.M.Sc.2017.Ay.G
100	0		_aAya Ibrahim Mohamed
245	1	0	_aGrowth and pubertal pattern in Egyptian children with sickle cell disease / _cAya Ibrahim Mohamed ; Supervised Khaled Mohamed Salama , Huda Marzouk Mohamed , Mohamed Mohamed Ismail
246	1	5	_aدارسه نمط النمو و البلوغ للأطفال المصريين مرضى أنيميا الخلايا المنجلية
260			_aCairo : _bAya Ibrahim Mohamed , _c2017
300			_a99 P. : _bcharts ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics
520			_aSickle cell disease (SCD) is one of the most common severe monogenic disorders in the world. Hemoglobin polymerization, leading to erythrocyte rigidity and vaso-occlusion, is central to the pathophysiology of this disease. Physical growth is known to be impaired in SCD and affected children are usually lighter and shorter than their healthy counterparts. The prevalence and severity of growth impairment vary with geographical location and are most marked in low-resource settings. Causes of growth retardation in SCD are complex and multiple factors are likely to contribute. The aim of our work was to study growth pattern in sickle cell patients, and to detect differences in growth parameters between sickle SS and sickle Ý. also to detect correlation between blood transfusion, vaso occlusive crises, serum ferrittin and some parameters of growth in the two groups (SS and SÝ). This study was conducted on 80 patients with sickle cell disease (50 sickle SS and 30 SÝ), who were following up at the pediatric hematology clinic, Cairo university and another 50 age-and sex- matched healthy children were enrolled as controls. Growth assessment was done using WHO reference values z-score and pubertal assessment using tanner stage. The study revealed that growth and puberty were affected in all patients with SCD, while there were no significant differences in growth and pubertal parameters between sickle SS and sickle Ý except for body mass index. There for regular and close up of the patients growth and pubertal signs should be performed for detection of any delay and it`s subsequent management
530			_aIssued also as CD
653		4	_aGrowth
653		4	_aPuberty
653		4	_aSickle cell disease
700	0		_aHuda Marzouk Mohamed , _eSupervisor
700	0		_aKhaled Mohamed Salama , _eSupervisor
700	0		_aMohamed Mohamed Ismail , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c63080 _d63080