000			03053cam a2200349 a 4500
003			EG-GiCUC
005			20250223031838.0
008			171107s2017 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.11.10.Ph.D.2017.Na.E
100	0		_aNadia Mohamed Shoukry
245	1	0	_aExpression of B and T iymphocyte attenuator, retinoid-related orphan receptor gamma-Isoform-t and interleukin 7 in psoriasis vulgaris / _cNadia Mohamed Shoukry ; Supervised Randa Mohammad Youssef , Amany Zaki Elramly , Marwa Fathy Hussein
246	1		_aو انترلوكين7 فى الصدفيه التقليدية T الليمفاوية: مستقبل ريتينويد ذات الصلة جاما T و B التعبير الجينى لمضاعفات خلايا
260			_aCairo : _bNadia Mohamed Shoukry , _c2017
300			_a122 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology
520			_aPsoriasis is one of the immune-mediated inflammatory diseases (IMID); Both CD4⁺ T lymphocytes mainly Th1 cells and B lymphocytes contribute in the pathogenesis of IMIDs through the proinflammatory effect and production of antibodies, activation of T cells, cytokine synthesis respectively. Gamma delta (Þe) T cells are capable of producing large amounts of IL-17 upon IL-23 stimulation. The capacity of Þe T cells to produce IL-17 is acquired during thymic differentiation, independent of TCR signaling, a feature pointing to their innate nature. B and T lymphocyte attenuator (BTLA) is a coinhibitory molecule expressed on T and B lymphocytes as well as other immune cells, it is necessary to inhibit homeostatic expansion and activation of lymph node and skin resident Þe T cells. BTLA expression is regulated by RORÞt and IL-7. RORÞt is a key transcription factor driving the Th17 differentiation producing IL-17 which plays a major role in psoriasis pathogenesis. IL-7 plays a role in psoriasis pathogenesis and is also critical for the normal homeostasis, function, expansion, and survival of adult Þe Tcells. Aim of study: To add more insight to the role played by co-inhibitory molecule BTLA in psoriasis vulgaris patients, by studying the gene expression of BTLA, RORÞt and IL-7 in psoriasis patients. It also aimed to analyze their inter-relationship. This aims at establishing a basis for novel treatment strategies for psoriasis. Patients and methods: This case control study included 25 patients and 25 controls examined for gene expression of BTLA, RORÞt and IL-7
530			_aIssued also as CD
653		4	_a BTLA
653		4	_aPsoriasis
653		4	_aÞe T cells
700	0		_aAmany Zaki Elramly , _eSupervisor
700	0		_aMarwa Fathy Hussein , _eSupervisor
700	0		_aRanda Mohammad Youssef , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c63339 _d63339