000			03048cam a2200325 a 4500
003			EG-GiCUC
008			171111s2017 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.08.08.M.Sc.2017.Da.P
100	0		_aDalia Ali Farghaly Ibrahim
245	1	0	_aPreparation of an anti-inflammatory drug in different dosage forms for topical application / _cDalia Ali Farghaly Ibrahim ; Supervised Magdy Ibrahim Mohamed , Ahmed Abdelfattah Aboelwafa , Manal Yassin Hamza
246	1	5	_aتحضير عقار مضاد للالتهاب فى أشكال صيدلية مختلفة للاستعمال السطحى
260			_aCairo : _bDalia Ali Farghaly Ibrahim , _c2017
300			_a184 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics
520			_aThe aim of this study was to formulate fenoprofen calcium (FPCa) in different topical dosage forms; namely microemulsion and spanlastic gel to eliminate its oral gastrointestinal adverse effects. Microemulsion was prepared by the water titration method using oleic acid as oil phase, tween 80 or cremophor EL as surfactants and propylene glycol or transcutol P as cosurfactants. Oleic acid was selected as oil phase due to its good solubilizing capacity. Microemulsion existence region was determined using pseudo-ternary phase diagrams for preparing different formulations. Six different formulations were selected with various values of oil (25-68%), water (2-3%), and the mixture of tween 80 and propylene glycol (1:1) (24-67%). The selected microemulsion formulae were characterized for optical birefringence, transmission electron microscopy, pH, % transmittance, electronic conductivity, drug content, droplet size, rheological properties and stability evaluation. In-vitro release study of fenoprofen calcium from microemulsions through the synthetic membrane and hairless rat skin were evaluated. The optimized formula ME5 consisting of 5% w/w fenoprofen calcium, 60% w/w oleic acid as oil phase, 3% w/w aqueous phase, and 32% w/w of surfactant phase containing Tween 80 and propylene glycol (1:{u2009}1) showed the highest transdermal flux and highest skin permeation rate. FPCa-loaded spanlastics were prepared by thin-film hydration (TFH) technique according to a full factorial design (23) to investigate the influence of formulation variables on the drug entrapment efficiency (%EE), particle size (PS), deformability index (DI), and the % drug released after 24hs through the cellulose membrane (Q24h) using design-expert® software
530			_aIssued also as CD
653		4	_aFenoprofen calcium
653		4	_aMicroemulsion
653		4	_aTopical delivery
700	0		_aAhmed Abdelfattah Aboelwafa , _eSupervisor
700	0		_aMagdy Ibrahim Mohamed , _eSupervisor
700	0		_aManal Yassin Hamza , _eSupervisor
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c63369 _d63369