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008 171120s2017 ua o f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.12.18.M.Sc.2017.Kh.P
100 0 _aKhaled Mohamed Saad Elgeshy
245 1 4 _aThe possible associated MicroRNAs in Egyptian hepatocellular carcinoma patients infected with hepatitis C virus /
_cKhaled Mohamed Saad Elgeshy ; Supervised Elsayed Tarek Abdelsalam , Abeer Mostafa Ashmawy , Mohammed Ghareeb Mahmoud
246 1 5 _aالترابط المحتمل بين جزيئات الحمض الريبوزى النووى الدقيقة فى سرطانة الخلية الكبدية للمرضى المصريين المصابين بفيروس التهاب الكبد الوبائى - سى
260 _aCairo :
_bKhaled Mohamed Saad Elgeshy ,
_c2017
300 _a148 P. :
_bphotographs ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Microbiology
520 _aIntroduction: MiRNA play an important role in carcinogenesis and cancer progression specially those associated with viral infection as HCC through different pathways, one of them Wnt/Ý-catenin pathway. Aim of the work: An attempt to uncover the association between liver-related miRs with Wnt/ Ý- catenin pathway proteins in HCC patients infected with HCV. Methods: Wnt/ Ý-catenin pathway proteins were examined using IHC, total RNA [including miRs] extraction performed on samples from the same patients, real time-PCR was performed on the examined miRs, these data were correlated using SPSS for windows software. Results: 6 out of 13 miRs showed significant correlation with 3 out of 5 Wnt/ Ý-catenin pathway proteins. Conclusion: miR-10a, miR- 30e, miR-106b, miR-125b, miR-148a and miR-215 were highly associated with Wnt/ Ý-catenin pathway in HCC cases infected with HCV
530 _aIssued also as CD
653 4 _aHCC
653 4 _aHCV
653 4 _aMicroRNA
700 0 _aAbeer Mostafa Ashmawy ,
_eSupervisor
700 0 _aElsayed Tarek Abdelsalam ,
_eSupervisor
700 0 _aMohammed Ghareeb Mahmoud ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aSamia
_eCataloger
942 _2ddc
_cTH
999 _c63573
_d63573