000			03100cam a2200349 a 4500
003			EG-GiCUC
005			20250223031848.0
008			171126s2017 ua h f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.11.21.Ph.D.2017.Mo.C
100	0		_aMohamed Taha Mohamed
245	1	0	_aCognitive functions and neurophysiological changes among patients with tramadol dependence / _cMohamed Taha Mohamed ; Supervised Mohamed Ezzat Arafa , Hani Hamed Dessoki , Hala Fakhry Abdelsalam
246	1	5	_aالوظائف المعرفية و التغيرات الفسيولوجية العصبية فى المرضى الذين يعانون من الإعتماد على الترامادول
260			_aCairo : _bMohamed Taha Mohamed , _c2017
300			_a415 P. : _bfacsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Neuropsychiatry
520			_aObjective: This study is an observational, analytic, case-control study aiming at assessment of the cognitive functions and neurophysiological changes in tramadol dependent patients and finding correlation between cognitive functions impairment and seizures in the same patients. Method: Subjects participating in this study were 100 subjects divided into 2 groups: Patient group: (n = 50) patients using tramadol as a primary substance of dependence according to DSM IV TR diagnostic criteria of substance dependence (American psychiatric association, 2000), control group: (n=50) healthy control subjects with negative current and past history of substance abuse/dependence. All participants gave written consent and were subjected to the following interviews, assessments and investigations (except addiction severity index (ASI) done only for patient group: Psychiatric assessment using The Mini International Neuropsychiatric Interview (M.I.N.I), addiction severity index (ASI), wechsler memory scale-revised (WMS-R), boston naming test-2 (BNT-2) verbal fluency tests (Letter fluency and category fluency), wisconsin card sorting test (WCST-computer-administered version), urine sampling using drug screening strips, event related potential (P300) and electroencephalography (EEG). Results: Tramadol dependent patients showed significantly worse Wechsler memory, worse boston naming test, worse verbal fluency test and decreased P300 amplitude than the healthy control. Conclusion: Tramadol dependence is associated with deterioration in certain domains of cognitive performance, mainly the general memory assessment, attention, concentration, psychomotor speed, visuospatial function and visual naming ability
530			_aIssued also as CD
653		4	_aCognitive functions
653		4	_aSeizures
653		4	_aTramadol
700	0		_aHala Fakhry Abdelsalam , _eSupervisor
700	0		_aHani Hamed Dessoki , _eSupervisor
700	0		_aMohamed Ezzat Arafa , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c63698 _d63698