000			03134cam a2200349 a 4500
003			EG-GiCUC
005			20250223031848.0
008			171127s2017 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.07.M.Sc.2017.Ra.R
100	0		_aRasha Fawzy Ahmed Elsebaey
245	1	0	_aRole of vascular endothelial growth factor (VEGF+963 C>T) and basic fibroblast growth factor (bFGF-921C>G) gene polymorphisms in B-Cell chronic lymphocytic leukemia / _cRasha Fawzy Ahmed Elsebaey ; Supervised Hoda Mohamed Abdelghany , Nadia Ibrahim Sewelam , Noha Yehia Abdou Ibrahim
246	1	5	_aالتعدد الشكلى لجين عامل نمو الخلايا المبطنه للأوعيه الدمويه و جين عامل نمو الخلايا الليفيه الأساسى فى سرطان الدم الليمفاوى المزمن
260			_aCairo : _bRasha Fawzy Ahmed Elsebaey , _c2017
300			_a159 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
520			_aBackground: Vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) dependent angiogenesis in chronic lymphocytic leukemia (CLL) have been reported in several studies. Single nucleotide polymorphisms (SNPs) in VEGF and bFGF genes could regulate their cellular expression and consequently affect CLL disease progression. Aim of work: The aim of the present study was to determine the relation between VEGF+936 C>T and bFGF-921 C>G polymorphisms and B-CLL disease severity. Material and methods: The study was conducted on 50 CLL patients and 50 age and sex matched healthy adults. Polymerase chain reaction restriction fragment length Polymorphism (PCR-RFLP) technique was performed for the detection of VEGF+936 C>T and bFGF-921 C>G polymorphisms. Results: VEGF mutant genotypes (CT and TT), allele (T), and bFGF mutant genotypes (CG and GG), allele (G) were slightly higher among CLL patients compared to controls, with no statistical significance (p-value =0.414, 0.298, 0.422 and 0.524). No difference in VEGF and bFGF allele or genotype distribution was detected between subgroups with stages 0-II versus III-IV according to Rai staging (p-value =0.243 and 0.909). Conclusion: our study did not detect significant relationships for VEGF or bFGF polymorphisms and susceptibility to B- CLL or progression of the disease. Relating the VEGF and bFGF polymorphisms in future studies to the corresponding growth factor gene expression and plasma levels is advised to clarify association with disease pathophysiology and disease progression
530			_aIssued also as CD
653		4	_aCLL
653		4	_aGenetic polymorphism
653		4	_aVEGF
700	0		_aHoda Mohamed Abdelghany , _eSupervisor
700	0		_aNadia Ibrahim Sewelam , _eSupervisor
700	0		_aNoha Yehia Abdou Ibrahim , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c63707 _d63707