000			02164cam a2200349 a 4500
003			EG-GiCUC
005			20250223031858.0
008			171216s2017 ua dho f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.12.02.Ph.D.2017.Ay.D
100	0		_aAyat Gamal Ali Ahmed
245	1	0	_aDiscovery of new selective antagonists for cell apoptosis inhibitor proteins as novel anticancer agents / _cAyat Gamal Ali Ahmed ; Supervised Abdou Osman Abdelhamid , Mervat Elsayed Mohamed , Magda Fikry Mahmoud
246	1	5	_aإكتشاف مضادات إنتقائية جديدة للبروتينات المثبطة لعملية الموت الممنهج للخلايا كعوامل جديدة مضادة للسرطان
260			_aCairo : _bAyat Gamal Ali Ahmed , _c2017
300			_a175 P. : _bcharts , facsimiles , photographs ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry
520			_aIn this study, four new adamantane thiadiazole derivatives (ATDs) were designed and theoretically tested for their binding affinities to a model of an apoptosis inhibitor protein using molecular modeling. ATD-4, that showed the highest binding affinity, was synthesized, characterized and screened for its cytotoxic activity against different cancer cell lines as well as normal cell line using 5-fluorouracil as a reference organic drug. Inducing apoptosis in lung carcinoma cell line was studied by various biochemical and morphological methods. Results indicate that ATD-4 exerted its cytotoxic activity against A549 cells through the induction of the intrinsic (mitochondrial) apoptotic pathway
530			_aIssued also as CD
653		4	_aAdamantane thiadiazole derivatives
653		4	_aCytotoxicity
653		4	_aMolecular modeling
700	0		_aAbdou Osman Abdelhamid , _eSupervisor
700	0		_aMagda Fikry Mahmoud , _eSupervisor
700	0		_aMervat Elsayed Mohamed , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c64042 _d64042