| 000 | 02798cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223031904.0 | ||
| 008 | 171226s2017 ua h f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.12.02.Ph.D.2017.No.S | ||
| 100 | 0 | _aNoha Sayed Hamed Awad | |
| 245 | 1 | 0 |
_aStudy of some biochemical markers in female patients with transfusion dependent Ý-thalassemia / _cNoha Sayed Hamed Awad ; Supervised Mervat Elsayed Mohamed , Mohamed Ali Eldesouky , Samir Mostafa Abdelaziz |
| 246 | 1 | 5 | _aدراسه بعض الدلالات الكيميائيه الحيويه فى الأناث المصابات بأنيميا البحر المتوسط و المعتمدات على نقل الدم |
| 260 |
_aCairo : _bNoha Sayed Hamed Awad , _c2017 |
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| 300 |
_a101 P. : _bfacsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry | ||
| 520 | _aThe deleterious effect of iron overload on anti-müllerian hormone (AMH) level, as a best test to investigate ovarian reserve, was evaluated in 90 female patients with thalassemia major (TM), intermedia (TI) and minor, osteoporosis detection through measurement of bone mineral density (BMD z-score) using DXA and laboratory diagnosis. Also, to investigate the effects of iron chelation therapy including deferiprone and deferoxamine in the management of transfusion-related iron overload. The present results revealed that Serum AMH level was lower in female patients with transfusion dependent Ý-thalassemia than in thalassemia minor also, Ferritin was 25 fold more in thalassemia major compared to thalassemia minor (3088.0±2497.6 ng/ml vs. 120.3±36.2 ng/ml). There was significant negative correlation of AMH with ferritin in all thalassemic females. The prevalence rate of osteoporosis, based on the WHO criteria was 3.3% in thalassemia major and the prevalence of osteopenia was 93.3% in thalassemia major and 30% in thalassemia intermedia. The present finding implied a significantly higher ferritin, higher PTH, higher osteocalcin and lower AMH in patients with thalassemia major that used deferoxamine than deferiprone. In conclusion, patients with thalassemia major and intermedia constitute a high risk group due to higher ferritin concentrations and iron overload | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aAnti-Müllerian hormone | |
| 653 | 4 | _aFerritin | |
| 653 | 4 | _aOsteoporosis | |
| 700 | 0 |
_aMervat Elsayed Mohamed , _eSupervisor |
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| 700 | 0 |
_aMohamed Ali Eldesouky , _eSupervisor |
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| 700 | 0 |
_aSamir Mostafa Abdelaziz , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aSamia _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c64248 _d64248 |
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