| 000 | 02028cam a2200313 a 4500 | ||
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| 003 | EG-GiCUC | ||
| 008 | 171225s2017 ua f m 000 0 eng d | ||
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_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.08.05.M.Sc.2017.Ma.S | ||
| 100 | 0 | _aMai Ibrahim Aboelmagd Ali | |
| 245 | 1 | 0 |
_aSynthesis and anticonvulsant evaluation of certain moieties derived from diazaspiroalkanediones / _cMai Ibrahim Aboelmagd Ali ; Supervised Mohamed Nabil Aboul-Enein , Kamilia Mahmoud Amin |
| 246 | 1 | 5 | _aتشييد وتقييم الفاعلية المضادة للتشنجات لبعض الجزيئات المشتقة من ثنائي ازاسبيرو الكان داي اون |
| 260 |
_aCairo : _bMai Ibrahim Aboelmagd Ali , _c2017 |
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| 300 |
_a147 P. ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry | ||
| 520 | _aThis work deals with the synthesis of novel structures of: 1-[(2-hydroxyethyl)(aryl)amino]-N-substituted cycloalkanecarboxamides (IXa-l) and 2-[(1-substituted carbamoyl)cycloalkyl)(aryl)amino] ethyl acetates (Xa-l) derived from certain diazaspiroalkanediones. The newly synthesized compounds displayed an anticonvulsant activity using the subcutaneous pentylenetetrazole (scPTZ) and maximal electroshock seizure (MES) tests. The compounds were devoid of neurotoxicity in rotarod test. The most potent compounds in the scPTZ screen were Xh, Xd, Xf, IXj, Xl and Xi. Compound Xf was active as a new anticonvulsant agent in both scPTZ and MES screens. Also, a molecular modeling study was performed for the designed target compounds using Autodock 1.5.6 | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aAnticonvulsant | |
| 653 | 4 | _aDiazaspiroalkanediones | |
| 653 | 4 | _aMolecular modeling | |
| 700 | 0 |
_aKamilia Mahmoud Amin , _eSupervisor |
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| 700 | 0 |
_aMohamed Nabil Aboul-Enein , _eSupervisor |
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| 905 |
_aNazla _eRevisor |
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| 905 |
_aShimaa _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c64263 _d64263 |
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