| 000 | 02765cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223031917.0 | ||
| 008 | 180122s2017 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.11.16.Ph.D.2017.Kh.P | ||
| 100 | 0 | _aKhaled Ragab Abdelhakim | |
| 245 | 1 | 0 |
_aPossible protective effect of melatonin on cisplatin-induced testicular toxicity in adult albino rats : _bA histological and immunohistochemical study / _cKhaled Ragab Abdelhakim ; Supervised Soheir Assaad Filobbos , Noha Mohamed Afifi Amin , Mira Farouk Youssef |
| 246 | 1 | 5 |
_aالتأثير الوقائي المحتمل للميلاتونين علي سمية الخصية المستحث بالسيسبلاتين في الجرذان البيضاء البالغة : _bدراسة هستولوجية و هستوكيميائية مناعية |
| 260 |
_aCairo : _bKhaled Ragab Abdelhakim , _c2017 |
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| 300 |
_a175 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Histology | ||
| 520 | _aChemotherapy may result in temporary or permanent gonadal toxicity in male patients. Loss of fertility potential can be devastating to patients, especially, during the child-bearing period. The present study was planned to investigate the possible protective effect of melatonin, in a rat model of cisplatin-induced testicular toxicity. Forty five adult male albino rats were divided into four groups; Group I Control (n=15) received 0.9% sodium chloride and/or distilled water as a vehicle. Group II (n=10) were injected intraperitoneally (I.P.) with a single dose 7 mg/kg of cisplatin & were sacrificed after 10 days. Group III (n=10) received melatonin daily orally at a dose of 8 mg/kg/day for 10 days. Group IV (n=10); oral melatonin administration started 5 days before the single I.P. injection of cisplatin, followed by continuation of melatonin for further 10 days. Testicular sections were subjected to H&E, immunohistochemical staining for anti-inducible nitric oxide synthase (iNOS) and anti-androgen receptor (AR). The study proved the protective effect of melatonin against testicular toxicity, when administered prior to and concomitant with cisplatin therapy; confirming the anti-oxidant potential of melatonin | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aCisplatin | |
| 653 | 4 | _aMelatonin | |
| 653 | 4 | _aRat testis | |
| 700 | 0 |
_aMira Farouk Youssef , _eSupervisor |
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| 700 | 0 |
_aNoha Mohamed Afifi Amin , _eSupervisor |
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| 700 | 0 |
_aSoheir Assaad Filobbos , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aEnas _eCataloger |
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| 905 |
_aNazla _eRevisor |
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| 942 |
_2ddc _cTH |
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| 999 |
_c64645 _d64645 |
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