| 000 | 02752cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223031921.0 | ||
| 008 | 180131s2017 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
||
| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.11.07.Ph.D.2017.Re.C | ||
| 100 | 0 | _aReem Mohamed Ahmed Embaby | |
| 245 | 1 | 0 |
_aClinical role of micro-rnas expression in acute myeloid leukemia : _bmiR-155, miR-424 deregulation, correlation With NPM1 / _cReem Mohamed Ahmed Embaby ; Supervised Laila Abdelrahman Hegazy , Hanan Ramadan Nassar , Nohair Soliman |
| 246 | 1 | 5 | _aالدور الاكلينيكي للتعبير عن الحامض النووي الريبي الدقيق بنوعيه 155 و 424 في حالات سرطان الدم الميلودي الحاد وعلاقته مع جين النيكليوفوزمين |
| 260 |
_aCairo : _bReem Mohamed Ahmed Embaby , _c2017 |
||
| 300 |
_a149 P. : _bcharts , facsimiles ; _c25cm |
||
| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology | ||
| 520 | _aAML is a highly heterogeneous disease characterized by failure of myeloid precursor cells to undergo terminal differentiation from proliferating precursor cells into mature blood cells. MicroRNAs (miRNAs) are small, non-coding RNAs control the expression of a number of genes involved in commitment and differentiation of hematopoietic stem cells and tumorigenesis. The study aimed to clarify role of miR-155,mir-424,in pathogenesis ,prognosis of AML and correlation of both miRNAs with NPM1 gene .The present study done on 40 adult newly diagnosed AML cases that were taken from National Cancer Inistitute & medical oncology unit Kasr Aini School of Medicine, Cairo University and 40 sex & age matched controls. A quantitative reverse-transcription PCR (qRT-PCR) assay was done to relatively quantify miR-424,miR-155. (RT-PCR) assay was done to assess NPM1 mutation and correlate it with both micro-RNAs.There was highly statistically significant difference in miR-424 between both patients and controls (p=0.0001),miR 155 was a bad predictor for AML cases. No correlation was found between miR -424, miR-155 and NPM1 .So that deregulated expression of both miRNAs does not depend on NPM1 to exhibit its role in leukemogenesis | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aAcute Myeloid Leukemia | |
| 653 | 4 | _amiR-155 | |
| 653 | 4 | _amiR-424 | |
| 700 | 0 |
_aHanan Ramadan Nassar , _eSupervisor |
|
| 700 | 0 |
_aLaila Abdelrahman Hegazy , _eSupervisor |
|
| 700 | 0 |
_aNohair Soliman , _eSupervisor |
|
| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
||
| 905 |
_aShimaa _eCataloger |
||
| 942 |
_2ddc _cTH |
||
| 999 |
_c64763 _d64763 |
||